Steven Meshnick, MD, PhD

Meshnick, Steve

Professor

Epidemiology

3301 Michael Hooker Research Center, CB #7435

919.966.7414

meshnick@email.unc.edu

 

 

Research

My research involves the intersection of epidemiology and molecular biology. We are particularly interested in malaria, Pneumocystis jirovecii, and mother-to-child transmission of HIV.

Work in the lab is done in conjunction with epidemiological studies in Malawi, DR Congo, Thailand and Cambodia. Using specimens from human drug trials, we are studying the evolution of drug resistance and developing new tools to detect resistance in malaria and pneumocystis. We are also using blood and tissue samples from malaria and HIV infected pregnant women to understand the pathogenesis of malaria and HIV during pregnancy and the mechanisms of mother-to-child transmission.

Our lab is also working on the mechanisms of action of antimalarial drugs.

Publications

Mumba D, Bohorquez E, Messina J, Kande V, Taylor SM, Tshefu AK, Muwonga J, Kashamuka MM, Emch M, Tidwell R, Büscher P, Meshnick SR (2011). Prevalence of human african trypanosomiasis in the democratic republic of the congo. PLoS Negl Trop Dis. 5(8):e1246.

Vaughn MF, Meshnick SR (2011). Pilot study assessing the effectiveness of long-lasting permethrin-impregnated clothing for the prevention of tick bites. Vector Borne Zoonotic Dis. 11(7):869-75.

Taylor SM, Messina JP, Hand CC, Juliano JJ, Muwonga J, Tshefu AK, Atua B, Emch M, Meshnick SR (2011). Molecular malaria epidemiology: mapping and burden estimates for the Democratic Republic of the Congo, 2007. PLoS One. 6(1):e16420.

Hand CC, Meshnick SR (2011). Is chloroquine making a comeback? J Infect Dis. 203(1):11-2.

Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR; the NIAID Center for HIV/AIDS Vaccine Immunology. (2010). Correction: A whole genome association study of mother-to-child transmission of HIV in Malawi. Genome Med. 2(10):76.

Juliano JJ, Porter K, Mwapasa V, Sem R, Rogers WO, Ariey F, Wongsrichanalai C, Read A, Meshnick SR (2010). Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.
Proc Natl Acad Sci U S A. 107(46):20138-43.

Rantala AM, Taylor SM, Trottman PA, Luntamo M, Mbewe B, Maleta K, Kulmala T, Ashorn P, Meshnick SR (2010). Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women. Malar J. 9:269.

Messina JP, Emch M, Muwonga J, Mwandagalirwa K, Edidi SB, Mama N, Okenge A, Meshnick SR (2010). Spatial and socio-behavioral patterns of HIV prevalence in the Democratic Republic of Congo. Soc Sci Med. 71(8):1428-35.

Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR; the NIAID Center for HIV/AIDS Vaccine Immunology (2010). A whole genome association study of mother-to-child transmission of HIV in Malawi. Genome Med. 2(3):17.

Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Meshnick SR (2010). The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia. Trans R Soc Trop Med Hyg. 104(6):416-22.

Joubert BR, Franceschini N, Mwapasa V, North KE, Meshnick SR (2010). Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi. PLoS One. 5(2):e9212.

Juliano JJ, Gadalla N, Sutherland CJ, Meshnick SR (2010). The perils of PCR: can we accurately 'correct' antimalarial trials? Trends Parasitol. 26(3):119-24.

Taylor SM, Juliano JJ, Trottman PA, Griffin JB, Landis SH, Kitsa P, Tshefu AK, Meshnick SR (2010). High-throughput pooling and real-time PCR-based strategy for malaria detection. J Clin Microbiol. 48(2):512-9.

Juliano JJ, Ariey F, Sem R, Tangpukdee N, Krudsood S, Olson C, Looareesuwan S, Rogers WO, Wongsrichanalai C, Meshnick SR (2009). Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia. J Infect Dis. 200(4):624-8.

Juliano JJ, Taylor SM, Meshnick SR (2009). Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey? J Infect Dis. 200(1):5-7.

Purfield AE, Tidwell RR, Meshnick SR (2009). The diamidine DB75 targets the nucleus of Plasmodium falciparum. Malar J. 8:104.

Juliano JJ, Bacon DJ, Mu J, Wang X, Meshnick SR (2009). Novel dhps and pfcrt polymorphisms in Plasmodium falciparum detected by heteroduplex tracking assay. Am J Trop Med Hyg. 80(5):734-6.

Abrams ET, Meshnick SR (2009). Malaria during pregnancy in endemic areas: a lens for examining maternal-fetal conflict. Am J Hum Biol. 21(5):643-50.

Juliano JJ, Randrianarivelojosia M, Ramarosandratana B, Ariey F, Mwapasa V, Meshnick SR (2009). Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar. Malar J. 8:47.

Kwiek JJ, Mwapasa V, Alker AP, Muula AS, Misiri HE, Molyneux ME, Rogerson SJ, Behets FM, Meshnick SR (2008). Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004.
Malawi Med J. 20(3):80-5.

Alker AP, Kazadi WM, Kutelemeni AK, Bloland PB, Tshefu AK, Meshnick SR (2008). dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo. Trop Med Int Health. 13(11):1384-91.

Alvarez-Martínez MJ, Moreno A, Miró JM, Valls ME, Rivas PV, de Lazzari E, Sued O, Benito N, Domingo P, Ribera E, Santín M, Sirera G, Segura F, Vidal F, Rodríguez F, Riera M, Cordero ME, Arribas JR, Jiménez de Anta MT, Gatell JM, Wilson PE, Meshnick SR; Spanish PCP Working Group (2008). Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality. Diagn Microbiol Infect Dis. 62(1):34-43.

Juliano JJ, Trottman P, Mwapasa V, Meshnick SR (2008). Detection of the dihydrofolate reductase-164L mutation in Plasmodium falciparum infections from Malawi by heteroduplex tracking assay. Am J Trop Med Hyg. 78(6):892-4.

Kwiek JJ, Arney LA, Harawa V, Pedersen B, Mwapasa V, Rogerson SJ, Meshnick SR (2008). Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi. J Infect Dis. 197(10):1378-81.

Wongsrichanalai C, Meshnick SR (2008). Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis. 14(5):716-9.

Purfield AE, Tidwell RR, Meshnick SR (2008). Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro. Antimicrob Agents Chemother. 52(6):2253-5.

Lanteri CA, Tidwell RR, Meshnick SR (2008). The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrob Agents Chemother. 52(3):875-82.

Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Alker AP, Kwiek JJ, Meshnick SR (2007). A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. PLoS One. 2(11):e1166.

Pedersen BR, Kamwendo D, Blood M, Mwapasa V, Molyneux M, North K, Rogerson SJ, Zimmerman P, Meshnick SR (2007). CCR5 haplotypes and mother-to-child HIV transmission in Malawi. PLoS One. 2(9):e838.

Juliano JJ, Kwiek JJ, Cappell K, Mwapasa V, Meshnick SR (2007). Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi. Emerg Infect Dis. 13(6):872-7.

van Oosterhout JJ, Laufer MK, Perez MA, Graham SM, Chimbiya N, Thesing PC, Alvarez-Martinez MJ, Wilson PE, Chagomerana M, Zijlstra EE, Taylor TE, Plowe CV, Meshnick SR (2007). Pneumocystis pneumonia in HIV-positive adults, Malawi. Emerg Infect Dis. 13(2):325-8.

Alker AP, Lim P, Sem R, Shah NK, Yi P, Bouth DM, Tsuyuoka R, Maguire JD, Fandeur T, Ariey F, Wongsrichanalai C, Meshnick SR (2007). Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Am J Trop Med Hyg. 76(4):641-7.

Kwiek JJ, Alker AP, Wenink EC, Chaponda M, Kalilani LV, Meshnick SR (2007). Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections. Antimicrob Agents Chemother. 51(2):521-7.

Mwapasa V, Rogerson SJ, Kwiek JJ, Wilson PE, Milner D, Molyneux ME, Kamwendo DD, Tadesse E, Chaluluka E, Meshnick SR (2006). Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi. AIDS. 20(14):1869-77.

Alvarez-Martínez MJ, Miró JM, Valls ME, Moreno A, Rivas PV, Solé M, Benito N, Domingo P, Muñoz C, Rivera E, Zar HJ, Wissmann G, Diehl AR, Prolla JC, de Anta MT, Gatell JM, Wilson PE, Meshnick SR; Spanish PCP Working Group (2006). Sensitivity and specificity of nested and real-time PCR for the detection of Pneumocystis jiroveci in clinical specimens. Diagn Microbiol Infect Dis. 56(2):153-60.

Kwiek JJ, Mwapasa V, Milner DA Jr, Alker AP, Miller WC, Tadesse E, Molyneux ME, Rogerson SJ, Meshnick SR (2006). Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi. PLoS Med. 3(1):e10.

Wilson PE, Kazadi W, Alker AP, Meshnick SR (2005). Rare Congolese Plasmodium falciparum DHFR alleles. Mol Biochem Parasitol. 144(2):227-9.

Alker AP, Mwapasa V, Purfield A, Rogerson SJ, Molyneux ME, Kamwendo DD, Tadesse E, Chaluluka E, Meshnick SR (2005). Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrob Agents Chemother. 49(9):3919-21.

Abrams ET, Kwiek JJ, Mwapasa V, Kamwendo DD, Tadesse E, Lema VM, Molyneux ME, Rogerson SJ, Meshnick SR (2005). Malaria during pregnancy and foetal haematological status in Blantyre, Malawi. Malar J. 4:39.

Ngrenngarmlert W, Kwiek JJ, Kamwendo DD, Ritola K, Swanstrom R, Wongsrichanalai C, Miller RS, Ittarat W, Meshnick SR (2005). Measuring allelic heterogeneity in Plasmodium falciparum by a heteroduplex tracking assay. Am J Trop Med Hyg. 72(6):694-701.

Nelson AL, Purfield A, McDaniel P, Uthaimongkol N, Buathong N, Sriwichai S, Miller RS, Wongsrichanalai C, Meshnick SR (2005). pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border. Am J Trop Med Hyg. 72(5):586-92.

Complete list of publications

Affiliations

Microbiology and Immunology
School of Public Health-Epidemiology