Baric lab: Identifying host pathways that regulate disease outcomes

A recent article in mBio, ASM's open access journal, is from Ralph Baric's lab and describes a systems biology approach that combines transcriptomics, proteomics, and comparative biology to understand the mechanisms of acute lung injury. The result is identification and validation that the urokinase pathway has a major role in SARS-CoV pathogenesis. Postdoc Lisa Gralinski is the first author on this collaborative study; read the article "Mechanisms of severe acute respiratory syndrome Conronarvirus-induced acute lung injury" through PubMed.