de Silva and Baric labs: Molecular determinants of immunity to dengue

The current online Early Edition of PNAS features a collaboration between the labs of Aravinda de Silva and Ralph Baric that has broad implications for designing and improving vaccines for viral infections. They demonstrate that a specific region on the viral surface (the envelope domain I/II hinge) is the primary target for serotype-specific neutralizing antibodies following natural infection. See the article at the link below.