Science Magazine recently featured a study from Ed Miao's lab on how bacterial endotoxin is detected if it enters the cytoplasmic compartment of mammalian cells. The paper shows that caspase-11 is activated by cytoplasmic endotoxin and describes how certain pathogens can avoid cytoplasmic detection by modifying their LPS. The implications of this TLR4-indepedent response to endotoxin are also discussed in a Perspective article by Jon Kagan in the same issue. M&I student John Hagar is the lead author of the Miao lab article and M&I postdoc Youssef Aachoui is a co-author.
Read the original article through PubMed