Dittmer lab: Pinpointing the human genome mutations linked to viral lymphoma

A PNAS article from Dirk Dittmer’s group demonstrates how targeted next-generation sequencing allowed them to identify single nucleotide variants in patients with primary effusion lymphoma (PEL), a herpesvirus-associated cancer. One of the consistent mutations is in the gene encoding IL-1 receptor-association kinase 1 (IRAK1) and introduces a novel phosphorylation site. See the article at the link below.