Ting lab: Defining the roles of innate immune sensor AIM2

AIM2 is well known to be involved in activation of the inflammasome, but how AIM2 is linked to tumor suppression is not well understood. A new Nature Medicine article from M&I Professor Jenny Ting’s group shows that AIM2-mediated restriction of tumorigenesis in colitis-associated colon cancer is through a mechanism that is independent of inflammasome activation and inflammation. See the article at http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3908.html