Wan lab: Smad4 control of T cell function

Just published online in Immunity: Yisong Wan’s group demonstrates that Smad4 can regulate T cell proliferation independent of TGF-β, presumably by integrating a number of other signaling pathways. The work has implications for inflammation, automimmunity, and tumor immune surveillance. See the article at http://www.cell.com/immunity/abstract/S1074-7613(14)00486-5