Janelle C. Arthur, PhD

Janelle C. Arthur, PhD

Assistant Professor
6104 Marsico Hall
CB#7290
919-966-2206



Research

Our group seeks to understand how inflammation alters the pro-carcinogenic capabilities of the microbiota, with the long-term goal of targeting resident microbes as a preventative and therapeutic strategy to lessen inflammation and reduce the risk of colorectal cancer.  Our general approach combines genomics, bioinformatics, immunology, bacterial cultivation techniques and gnotobiotic mouse models to identify inflammatory and pro-carcinogenic bacteria from human patients and uncover mechanisms by which these bacteria promote inflammation and neoplasia.  We are currently focusing upon clinical strains of intestinal E. coli isolated directly from human inflammatory bowel disease (IBD) patients, who are known to experience a high risk of colorectal cancer.  We are evaluating the ability of these resident microorganisms to induce inflammation and tumorigenesis in mouse models and defining functional capabilities, microbial genes and pathways that are causally and mechanistically linked to carcinogenesis.  Ultimately this research will uncover novel microbial targets will enable us to manipulate the intestinal microbiota as a therapeutic target for human digestive diseases and cancer.

Publications

Arthur, J.C., Gharaibeh, R.Z., Muhlbauer, M., Perez-Chanona, E., Uronis, J.M., McCafferty, J., Fodor, A.A., Jobin, C. (2014) Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer. Nature Commun, Sep 3;5:4724. PMID 25182170.

Baker, K., Rath, R., Flak, M.B., Arthur, J.C., Chen, Z., Glickman, J.N., Zlobec, I., Karamitopoulou, E., Stachler, M.D., Odze, R.D., Lencer, W.I., Jobin, C., Blumberg, R.S. (2013)  FcRn in dendritic cells promotes homeostatic intestinal CD8+ T cell activation, IL-12 production, and protective immunity against colorectal cancer.  Immunity, Dec 12;39(6):1095-1107.  PMID 24290911.

Arthur, J.C., Gharaibeh, R.Z., Perez-Chanona, E., Sha, W., Tomkovich, S., Muhlbauer, M., Fodor, A.A., Jobin, C.  (2013) VSL#3 probiotic modifies mucosal microbial composition but does not protect against tumorigenesis in a model of colitis-associated colorectal cancer. Sci Rep, Oct 8;3:2868.  PMID 24100376.

McCafferty, J., Muhlbauer, M., Gharaibeh R.Z., Arthur, J.C., Perez-Chanona, E., Sha, W., Jobin, C., Fodor, A.A.  Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model.  (2013) ISME J, ePub July 4 doi:10.1038/ismej.2013.106.  PMID 23823492.

Allen, I.C., McElvania-TeKippe, E., Lich, J.D., Arthur, J.C., Sullivan, J.T., Braunstein, M., Ting, J.P.  (2013) Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis.  PLoS One, 8(4):e60842.  PMID 13577168.

Chen, L.C., Chen, Z., Baker, K., Halvorsen, E.M., Pires da Cunha, A., Flak, M.B., Gerber, G., Huang, Y.H., Hosomi, S., Arthur, J.C., Dery, K.J., Nagaishi, T., Beauchemin, N., Holmes, K.V., Ho, J.W., Shively, J.E., Jobin, C., Onderdonk, A.B., Bry, L., Weiner, H.L., Higgins, D.E., Blumberg, R.S.  (2012) The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.  Immunity Nov 16;37(5):930-46.  PMID 23123061.

Arthur, J.C., Perez-Chanona, E., Muhlbauer, M., Tomkovich, S., Uronis, J.M., Fan, T-J., Abujamel, T., Dogan, B., Campbell, B.J., Rogers, A.B., Rhodes, J.M., Simpson, K.W., Stintzi, A., Hansen, J.J., Keku, T.O., Fodor, A.A., Jobin, C.  (2012)  Intestinal inflammation targets cancer-inducing activity of the microbiota.  Science, Oct 5;338(6103):120-3.  PMID 22903521.

Holl, E.K, Roney, K.E., Allen, I.C., Steinbach, E., Arthur, J.C., Buntzman, A., Plevy, S., Frelinger, J., Ting, J.P.  (2012)  Plexin-B2 and Plexin-D1 in Dendritic cells: Expression and Il-12/Il-23p40 production. PLoS One, 2012;7(8):e43333.  PMId 22916243.

Allen, I.C., Lich, J.D., Wilson, J.E., Arthur, J.C., Davis, B.K., Schneider, M., Woodford, R.T., Roberts, R.A., Uronis, J.M., Herfarth, H.H., Jobin, C., Rogers, A.B., Ting, J.P.  (2012)  NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kB signaling.  Immunity, May 25;36(5):742-54.  PMID 22503542.

Gulati, A.S., Shanahan, M.T., Arthur, J.C., Grossniklaus, E., von Furstenberg R.J., Kreuk, L., Henning, S.J., Jobin, C., Sartor, R.B.  (2012)  Mouse background strain profoundly influences paneth cell function and intestinal microbial composition.  PLoS One, 2012:7(2):e32403.  PMID 22384242.

Bassaganya-Riera, J., Viladomiu, M., Pedragosa-Marín, M., De Simone, C., Carbo, A., Shaykhutdinov, R., Jobin, C., Arthur, J.C., Corl, B.A., Vogel, H., Storr, M., Hontecillas, R.  (2012)  Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR to suppress colitis.PLoS One. 2012;7(2):e31238.  PMID 22363592.

Allen, I.C., Lich, J.D., Arthur, J.C., Jania, C.M., Roberts, R.A., Callaway, J.B., Tilley, S.L., Ting, J.P.  (2012)  Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice.  PLoS One, 2012:7(1):e30612.  PMID 22291998.

Appleyard, C.B., Cruz, M.L., Isidro, A.A., Arthur, J.C., Jobin, C., De Simone, C.  (2011)  VSL#3 probiotic treatment delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer.  Am J Physiol Gastrointest Liver Physiol. Dec;301(6):G1004-13.  PMID 21903764.

Arthur, J.C., Lich, J.D., Ye, A., Allen, I.C., Gris, D., Wilson, J.E., Schneider, M., Roney, K.E., O’Connor, B.P., Moore, C.B., Morrison, A., Sutterwala, F.S., Bertin, J., Koller, B.H., Liu, Z., Ting, J.P.  (2010)  Cutting Edge:  NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.  J Immunol 185:4515-4519.  PMID 20861349.

Uronis, J.M.*, Arthur, J.C.*, Keku, T.O., Fodor, A.A., Carroll, I.M., Cruz, M.L., Appleyard, C.B., Jobin, C.  (2010)  Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.  Inflamm Bowel Dis 17(1):289-297.  PMID 20564535.

*Authors contributed equally

Arthur, J.C., Lich, J.D., Aziz, R.K., Kotb, M., Ting, J.P.  (2007)  Heat shock protein 90 associates with Monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.  J Immunol 179:6291-6296.  PMID 17947705.

Lich, J.D., Williams, K.L., Moore, C.B., Arthur, J.C., Davis, B.K., Taxman, D.J., Ting, J.P.  (2007)  Cutting Edge:  Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.  J Immunol 178:1256-1260.  PMID 17237370.

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