Nilu Goonetilleke, PhD

Nilu Goonetilleke, PhD

Assistant Professor
120 Mason Farm Road
GMB Level 2 RM2017
CB#7042
919-962-3129



Research

Goonetilleke Lab (G Lab) – T cell immunology, HIV-1 pathogenesis

Our research focuses on understanding the response of T cells to infections, particularly HIV-1. The CD8 T cell response to HIV-1 is robust and exerts ongoing immune pressure on the virus throughout infection. However, the contribution of CD8 T cells to control of HIV-1 viremia differs greatly between individuals. Studies in our lab are aimed at gaining understanding of the variable efficacy of CD8 T cells in natural infection. Ultimately, we hope to translate our results into the design and testing of T cell vaccines for either HIV-1 prevention or cure.

Current projects:

  • Studies of acute HIV-1 infection focusing on better understanding CD8 T cell immunodominance and T cell mediated control of viremia.
  • CD8 T cells and HIV-1 Cure

 

Selected publications:

 

2014

Campion S, Brodie TM , Fischer W, Korber BT, RossettiA , Goonetilleke N, McMichael AJ, Sallusto F

Proteome wide analysis of HIV specific naïve and memory CD4+ T cells in unexposed blood donors

J Exp Med

 

2014

Hayward AC, Fragaszy E, Bermingham A, Wang L, Copas A, Edmunds J, Ferguson N, Goonetilleke N, Harvey G, Kovar J, Lim M, Millett ERC, Pebody R, Nguyen-Van-Tam JS, McMichael A, Nazareth I, Watson JM, Johnson AM, Zambon M and the Flu Watch Group

Comparative burden and severity of seasonal and pandemic influenza: Results of the Flu Watch study – England 2006-2011Lancet

Respir Med

 

2013

Liu MK, Hawkins N, Ritchie A, Ganusov VV, Whale V, Brackenridge S, Li H, Pavlicek JW, Cai F, Rose-Abrahams M, Treurnicht F, Hraber P, Riou C, Gray C, Ferrari G, Tanner R, Ping L, Anderson JA, Swanstrom R , CHAVI Core B, Cohen M, Karim SS, Haynes B , Borrow P, Perelson AS, Shaw GM,. Hahn BH, Williamson C, Korber BT, Gao F, Self S, McMichael AJ, Goonetilleke N.

T cell immunodominance and epitope entropy determine HIV-1 escape.

J of Clinical

Investigation

 

2013

Goonetilleke N, McMichael AJ

Antigen processing takes a new direction

Science

2013

Goonetilleke N, McMichael AJ

HIV-1 vaccines: let's get physical

Immunity

2012

Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM , Goonetilleke N, Liu MK, Berg A, Hora B, Drinker M, Eudailey J, Pickeral J,Moody MA, Ferrari G, McMichael A,Perelson AS, Shaw GM, Hahn B, Haynes BF, Gao F.

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

Retrovirol

 

2012

Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, Whale V, Goonetilleke N, Borrow P, Ferrari G, Betts MR, Haynes BF, McMichael AJ, Gray CM.

Distinct Kinetics of Gag-Specific CD4+ and CD8+ T Cell Responses during Acute HIV-1 Infection.

JImmunol

 

2011

Ganusov S, Goonetilleke N, Liu M, Ferrari G, Shaw G, McMichael A, Borrow P, Korber B, Perelson A

Fitness costs and diversity of CTL response determine the rate of CTL escape during the acute and chronic phases of HIV-1 infection

J Virol

 

2011

Ferrari G, Korber B, Goonetilleke N, Liu M, Turnbull EL, Salazar-Gonzalez J, Hawkins N, Self S, Watson S, Betts M, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras G, Haynes B, Gray C, Borrow P, Roederer M, McMichael A, Weinhold K.

Relationship between functional profile of HIV01 specific CD8 T cels and epitope variability with the selection of escape mutants in acute HIV-1 infection

PLoS Pathog.

 

2011

Ritchie A, Campion S, Kopycinski J, Moore S, Brackenridge S, Liu MK, Kuldanek K, Legg K, Wang M, Pandya K, Delwart E, Fidler S, Moodie Z, McMichael A, Goonetilleke N.

Differences in HIV-1 specific T cell responses between HIV-exposed and unexposed HIV-1 seronegative individuals

J Virol

 

2011

Campion S, Cohen MS, McMichael AJ, Galvin S and Goonetilleke N

Improved detection of latent Mtb infection in HIV-1 seropositive individuals using cultured cellular assays

Eur J Immunol

 

2010

McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF.

The immune response during acute HIV-1 infection: clues for vaccine development.

Nat Rev

 

2009

 

 

Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, Keele BF, Learn GH, Turnbull EL, Salazar MG, Weinhold KJ, Moore S; CHAVI Clinical Core B, Letvin N, Haynes BF, Cohen MS, Hraber P, Bhattacharya T, Borrow P, Perelson AS, Hahn BH, Shaw GM, Korber BT, McMichael AJ.

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.

J Exp Med.

 

 

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