Wesley Burks, MD

Wesley Burks, MD

Professor
260 MacNider Building
CB# 7220
919-966-1505


Department of Pediatrics

Research

The UNC Food Allergy Institute (UNCFAI) was established in 2012 to address the growing needs of children and adults with food allergy. Program investigators study the biologic basis of food allergy in the laboratory and in clinical research studies seeking to better understand the role of allergen-specific IgE and the mechanism of allergen immunotherapy. The Institute provides comprehensive, family-centered patient care for food allergy, food-related anaphylaxis, and other related disorders like atopic dermatitis and eosinophilic esophagitis.

Publications

  1. Kulis M, Wan CK, Gorentla BK, Burks AW, Zhong XP. Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.  J Allergy Clin Immunol. 2011 Jul :128(1):212-4.
  2. Webb L, Peterson M, Boden S, LaBelle V, Bird JA, Howell D, Burks AW, Laubach S. Single-dose influenza vaccination of patients with egg allergy in a multicenter study.  J Allergy Clin Immunol. 2011 Jul;128(1):218-9.
  3. Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Consalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis:  Updated consensus recommendations for children and adults.  J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2.
  4. Vickery BP, Burks AW, Sampson HA. Anaphylaxis from peanuts ingested by blood donors?  N Engl J Med. 2011 Sep 1;365(9):867-8.
  5. Rancitelli P, Hofmann A, Burks AW.  Vaccine approaches for food allergy.  Curr Top Microbiol Immunol. 2011;352:55-69.
  6. Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa’ad A, Sampson HA.  NIAID-sponsored 2010 guidelines for managing food allergy:  applications in the pediatric population.  Pediatrics. 2011 Nov;128(5):955-65.
  7. Kulis M, Chen X, Lew J, Wang Q, Patel OP, Zhuang Y, Murray KS, Duncan MW, Porterfield HS, Burks AW, Dreskin SC.  The 2S albumin allergens of Arachis hypogaea Ara h 2 and Ara h 6 are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice.  Clin Exp Allergy. 2012 Feb;42(2):326-36.
  8. Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S, Steele P, Driggers S, Burks AW, Wood RA.  The safety and efficacy of sublingual and oral immunotherapy for milk allergy.  J. Allergy Clin Immunol. 2012 Feb;129(2):448-455.e5.
  9. Jacobsen RC, Guess TM, Burks AW.  Comparing activation and recoil forces generated by epinephrine autoinjectors and their training devices.  J Allergy Clin Immunol. 2012 Apr;129(4):1143-1145.e4. Epub 2011 Nov 10.
  10. Kulis M, Saba K, Kim EH, Bird JA, Kamilaris N, Vickery BP, Staats H, Burks AW.  Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy.  J Allergy Clin Immunol. 2012 Apr;129(4):1159-62. Epub 2012 Jan 10.
  11. Burks AW, Tang M, Sicherer S, Murano A, Eigenmann PA, Ebisawa M, Fiocchi A, Chiang W, Beyer K, Wood R, Hourihane J, Jones SM, Lack G, Sampson HA.  ICON:  Food Allergy. J Allergy Clin Immunol. 2012 Apr;129(4):906-20. Epub 2012 Feb 23.
  12. Lötvall J, Pawankar R, Wallace DV, Akdis CA, Rosenwasser LJ, Weber RW,Burks AW, Casale TB, Lockey RF, Papadopoulos NG, Fineman SM, Ledford DK, American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma & Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO).  We call for iCAALL:  International Collaboration in Asthma, Allergy and Immunology.  J Allergy Clin Immunol. 2012 Apr;129(4):904-5. Epub 2012 Feb 25.
  13. Lötvall J, Pawankar R, Wallace DV, Akdis CA, Rosenwasser LJ, Weber RW,Burks AW, Casale TB, Lockey RF, Papadopoulos NG, Fineman SM, Ledford DK, American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma & Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO).  We call for iCAALL:  International Collaboration in Asthma, Allergy and Immunology.  Ann Allergy Asthma Immunol. 2012 Apr;108(4):215-6.
  14. Burks AW, Jones SM, Wood, RA, Fleischer DM, Sicherer SH, Lindblad RW, Stablein D, Henning AK, Vickery BP, Liu AH, Scurlock AM, Shreffler WG, Plaut M, Sampson HA.  Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012 July 19;367(3):233-43.
  15. Ledford DK, Burks AW, Ballow M, Cox L, Wood RA, Casale TB.  Statement regarding “The public health benefits of air pollution control”. J Allergy Clin Immunol. 2012 Jul;130(1):24.
  16. Fleischer DM, Perry TT, Atkins D, Wood RA, Burks AW, Jones SM, Henning AK, Stablein D, Sampson HA, Sicherer SH.  Allergic reactions to food in preschool-aged children in a prospective observational food allergy study. Pediatrics. 2012Jul;130(1):e25-32.
  17. Thyagarajan A, Jones SM, Calatroni A, Pons L, Kulis M, Woo CS, Kamalakannan M, Vickery BP, Scurlock AM, Burks AW, Shreffler WG.  Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children.  Clin Exp Ellergy. 2012 Aug;42(8):1197-205.
  18. Kulis M, MacQueen I, Li Y, Guo R, Zhong XP, Burks AW.  Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy. J Allergy Clin Immunol. 2012 Sep;130(3):716-23.
  19. McWilliams LM, Mousallem T, Burks AW. Future therapies for food allergy, Hum Vaccin Immunother. 2012 Oct;8(10):1479-84.
  20. Sampson HA, Gerth can Wijk R, Bindslev-Jensen C, Sicherer S, Teuber SS,Burks AW, Dubois AE, Beyer K, Eigenmann PA, Spergel JM, Werfel T, Chinchilli VM. Standardizing double-blind, placebo-controlled oral food challenges:  American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol. 2012 Dec;130(6):1260-74.
  21. Land MH, Piehl MD, Burks AW. Near fatal anaphylaxis from orally administered gelatin capsule. J Allergy Clin Immunol Pract. 2013 Jan;1(1):99-100.
  22. Fleischer DM, Burks AW, Vickery BP, Scurlock AM, Wood RA, Jones SM, Sicherer SH, Liu AH, Stablein D, Henning AK, Mayer L, Lindblad R, Plaut M, Sampson HA; Consortium of Food Allergy Research (CoFAR). Sublingual immunotherapy for peanut allergy:  a randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol. 2013 Jan;131(1):119-27.e1-7.
  23. Vickery BP, Lin J, Kulis M, Fu Z, Steele PH, Jones SM, Scurlock AM, Gimenez G, Bardina L, Sampson HA, Burks AW. Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J Allergy Clin Immunol. 2013 Jan:131(1):128-34.e1-3.
  24. Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2013 Mar;131(3):805-812.
  25. Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, Nelson H, Akdis CA. Update on allergy immunotherapy:  American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol. 2013 May;131(5):1288-96.e3.
  26. Kulis M, Gorentla B, Burks AW.  Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens:  Modulation of sensitization and utility in a truncated immunotherapy regimen in mice. Mol Nutr Food Res. 2013 May;57(5):906-15
  27. Wood RA, Sicherer SH, Burks AW, Grishin A, Henning AK, Lindblad R, Stablein D, Sampson HA. A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy. 2013 Jun;68(6):803-8
  28. Calderon MA, Casale T, Cox L, Akdis CA, Burks AW, Nelson HS, Jutel M, Demoly P. Allergen immunotherapy:  a new semantic framework from the European Academy of Allergy and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report. Allergy.2013 Jul:68(7):825-8.
  29. Chin SJ, Vickery BP, Kulis MD, Kim EH, Varshney P, Steele P, Kamilaris J, Hiegel AM, Carlisle SK, Smith PB, Scurlock AM, Jones SM, Burks AW. Sublingual versus oral immunotherapy for peanut-allergic children:  A retrospective comparison. J Allergy Clin Immunol. 2013 Aug;132(2):476-478.e2.
  30. Shi X, Guo R, White BL, Yancey A, Sanders TH, Davis JP, Burks AW, Kulis M. Allergic properties of enzymatically hydrolyzed peanut flour extracts. Int Arch Allergy Immunol. 2013;162(2):123-30.
  31. Jones SM, Burks AW, Dupont C. State of the art on food allergen immunotherapy:  oral, sublingual and epicutaneous. J Allergy Clin Immunol. 2014 Feb;133(2):318-23.
  32. Vickery BP, Scurlock AM, Kulis M, Steele PH, Kamilaris J, Berglund JP, Burk C, Hiegel A, Carlisle S, Christie L, Perry TT, Pesek RD, Sheikh S, Virkud Y, Smith PB, Shamji MH, Durham SR, Jones SM, Burks AW. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol. 2014 Feb;133(2):468-475.
  33. Sicherer SH, Wood RA, Vickery BP, Jones SM, Liu AH, Fleischer DM, Dawson P, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol. 2014 Feb;133(2):492-9.
  34. Harvey BM, Langford JE, Harthoorn LF, Gillman SA, Green TD, Schwartz RH,Burks AW. Effects on growth and tolerance and hypoallergenicity of an amino acid-based formula with synbiotics. Pediatr Res. 2014 Feb;75(2):343-51.
  35. White BL, Shi X, Burk CM, Kulis M, Burks AW, Sanders TH, Davis JP. Strategies to mitigate peanut allergy:  production, processing, utilization, and immunotherapy considerations. Annu Rev Food Sci Technol. 2014;5:155-76.
  36. Plundrich NJ, Kulis M, White BL, Grace MH, Guo R, Burks, AW, Davis JP, Lila MA. Novel strategy to create hypoallergenic peanut protein-polyphenol edible matrices for oral immunotherapy. J Agri Food Chem. 2014 May 2 (epub ahead of print).
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