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UNC Chapel Hill supports a diverse array of phenotyping and genetic services for the mouse research community

Collaborative Cross Mouse Resource

  • CC Mice and Genotypes
  • Computational Genomics Tools
  • High Density Genotyping

Animal Model Generation

  • Transgenic mouse models
  • Knock-out mice/ ES Cell Targeting
  • CRISPR/Cas9 mediated mouse engineering
  • Transgenic and Knock-out rats

Gnotobiotic Model Generation

  • Germ-free Mice and Rats
  • Selectively Colonized Strains
  • Specialized Diets
  • Gavage Feeding
  • Rectal Instillation
  • Bone Marrow/HSC Transplant
  • IP injections of Immune Cells
  • Intestinal Surgery
  • Tissue collection

Animal Clinical Chemistry & Gene Expression

  • Blood Chemistry
  • Urinalysis
  • Hematology
  • Real-Time RTPCR

Animal Histopathology and Histology Research

  • Frozen and Paraffin Histology (Processing, embedding, sectioning, H&E and other staining)
  • Vibratome Sectioning for EM
  • IHC and ISH
  • Pathology Consulation

General Animal Studies

  • Aseptic Surgery
  • Orthotopic Injections
  • Tumor Passage
  • Tissue/Blood Studies
  • Intra-Cardiac (and other) Injections
  • IVIS imaging

Rodent Cardiovascular and Transplant Advanced Surgical Models

  • Heterotopic Heart, Renal, Liver, Pancreatic, Small Bowel, Esophageal/Tracheal, Unterine Horn, Transplantation
  • Aortic (Vascular) Graft Transplantation
  • Free Composite Tissue Vascularized Transplantation (both standard and custom-designed models)
  • Large-Vessel Electrolytic Injury, Collagen Induction, Mechanical Injury, Microvessel Laser Injury (with intravital fluorescence imaging and quantitative data analysis)
  • Microvessel, Carotid Artery Ferric Chloride Injury
  • Inferior Vena Cava Ligation (either total or partial ligation)
  • Saphenous Vein Laser Puncture or Stab Puncture Haemostasis Assay
  • Tail/Microvessel Bleed Assay (with intravital fluorescence imaging)

Mouse Behavioral Phenotyping

  • General Behavior Measures
  • Home Cage Behavior
  • Neurobehavioral Reflexes and Motor Function
  • Sensory Tasks
  • Anxiety, Depression-Related and Repetitive Behaviors
  • 3-Chamber Social Approach
  • Learning and Memory
  • Sensorimotor Gating
  • Neonatal Assessment

Animal Metabolism Phenotyping

  • Calorimetry
  • MRI
  • Voluntary Running Wheel and Treadmill

Animal Imaging

  • MRI
  • PET Imaging
  • SPECT Imaging
  • MicroCT Imaging
  • Ultrasound Imaging
  • Optical Imaging

Pre-Clinical Mouse Cancer Models

  • Administering treatments (IP, IV, subQ injections; medicated chow; etc)
  • Serial imaging (Ultrasound, IVIS, PET)
  • Pharmacology and pharmacokinetics
  • Molecular target validation
  • Tissue/Blood collection