| Name |
Keywords |
Research Interests |
| Anton, Eva |
radial glia, development, cortex, migration, cell adhesion |
The functional connectivity between neurons engendered by the laminar organization of the cerebral cortex is critical for normal cognitive function. Our aim is to understand the cellular and molecular mechanisms underlying neuronal migration and layer formation in the mammalian cerebral cortex. |
| Baldwin, Albert |
NFKB, Cancer |
The laboratory continues to focus on the regulation and biological functions of the transcription factor NF-kB and on the role of NF-kB in disease, with a particular emphasis on cancer and cancer therapy. These studies focus on the signaling pathways which target NF-kB, on the biological mechanisms which NF-kB controls, and on the ability of NF-kB to promote basic oncogenic mechanisms as well as resistance to cancer therapy. |
| Bhat, Manzoor |
Axon, Node of Ranvier, glia, drosophila, mice, neurexin |
Genetic Dissection of Axon-Glial Interactions in Drosophila and Mice |
| Brenman, Jay |
neurodevelopment, dendrites, axons, molecular genetics, GFP |
Molecular genetics to identify genes required for dendrite formation and neurodevelopment using Drosophila. |
|
Burmeister, Sabrina |
auditory processing, activity-dependent gene expression, neuroendocrinology, mate choice behavior, vocal communication, brain evolution |
Neural mechanisms of social behavior. |
| Cheney, Richard |
myosins, growth cones, motility |
Molecular biology and physiology of novel brain myosins and their involvement in neuronal function. |
| Crews, Stephen |
neurodevelopment, neurogenomics, neural and glial cell diversity, gene regulation |
Molecular genetic analysis of central nervous system development with special emphasis on Drosophila as a model system. |
| Deshmukh, Mohanish |
apoptosis, cell death, neurodegeneration, development, survival, nerve growth factor, transgenic mice |
Molecular mechanism of apoptosis in neurons. |
| Diatchenko, Luda |
|
Genomics and proteomics of orofacial pain - Identification of novel mediators of NF-kB signaling through genome-wide survey of monocyte-adherence-induced genes. - Currently developing a new method for identification of novel inhibitors of signaling pathways based on subtractive cloning |
| Goy, Michael |
second messengers; cyclic GMP; synaptic modulation; neuromuscular physiology |
Regulation of cyclic nucleotide function in neuromuscular, CNS, and gastrointestinal systems |
| Harden, T. Kendall |
G proteins, phospholipase C, RGS proteins, P2Y receptors, ecto-nucleotidase, protein structure/function, molecular pharmacology |
Regulation of phospholipase C and inositol lipid signaling; Structure/function of RGS proteins; Biology of nucleotides and nucleotide sugars as extracellular signaling molecules |
| Hodge, Clyde |
drug addiction, pharmacology, behavior, neural circuits, genetics, receptors |
Behavioral neurobiology and pharmacogenomics of drug abuse: Neural circuits and genes that mediate drug, self-administration and discrimination. |
| Hong, Jau-Shyong |
opioid peptides; neurotransmitters; gene expression; bovine adrenal chromaffin cells; hippocampus; seizures |
Regulation of opioids and tachykinins in the nervous system at the cellular and molecular level |
| LaMantia, Anthony |
early forebrain development, pattern formation, induction |
My laboratory studies the role of inductive signaling in the early regional development of the mammalian forebrain. |
| Lund, P Kay |
peptides, growth factors |
Regulation of the biosynthesis and expression of neuropeptides; function of growth factors in the CNS |
| Lysle, Donald |
neuroimmunology, behavior |
Psychoneuroimmunology; the effects of conditioning on lymphocyte reactivity |
| Maixner, William |
pain, electrophysiology, pharmacology |
Pharmacological and physiological mechanisms underlying the control of pain; role of hemodynamic factors in nociception |
| Maness, Patricia |
cell adhesion, development, oncogenes |
Oncogenes and their expression in the developing nervous system |
| Manis, Paul |
synaptic transmission, receptors, ion channels, potassium channels, spike-timing dependent plasticity, patch clamp, brain slice, single cell neural modeling, calcium imaging, quantitative real-time PCR, single cell PCR |
Cellular mechanisms of auditory information processing and plasticity. Studies examine ion channels and synaptic function and plasticity in the brainstem and cortex. |
| Matsushima, Glenn |
myelin, glia, cytokines, demyelination |
Cytokines and MHC genes in the processes of neuronal myelination and demyelination |
| McCarthy, Kenneth |
glial cells, calcium signaling |
Regulation of intracellular calcium and glial cell function by neurotransmitter action; regulation of glial cell phenotype |
| Morrow, A Leslie |
GABA-A receptor, mRNA regulation, ethanol, barbiturates, benzodiazepines, neuroactive steroids |
Molecular Neuropharmacology, Mechanisms of Receptor Regulation, Alcohol Research, GABA-A Receptors |
| Nicholas, Robert |
receptors, purinergic receptors, G-proteins |
Regulation and function of G-protein coupled receptors in the CNS |
| Pevny, Larysa |
stem cells, development, cell fate, genetics, Neural induction, neurogenesis, SOX proteins |
Studies of neural stem cells and cell differentiation during early embrygenesis. Focus on the SOX family of transcription factors and their role in specifying neurons. |
| Philpot, Benjamin |
synaptic plasticity, visual system, ocular dominance, LTP, LTD, NMDA receptors, cortex |
We are studying how visual experience modifies the properties of synaptic plasticity (LTP and LTD) so that the visual world can be properly analyzed. We use brain slice preparations from transgenic mice. These studies will characterize how experience regulates the elementary properties of plasticity and excitatory synaptic transmission. |
| Polleux, Franck |
development, ephrins, cortex, signaling pathways |
Identification of the cues and signaling pathways underlying the development of connections in the mammalian cerebral cortex |
| Roth, Bryan |
phramacology, G-proteins, serotonin, opoid receptors |
Serotonin (5-hydroxytryptamine; 5-HT) and opioid receptors are involved in the actions of drugs used in treating a large number of illnesses including depression, schizophrenia, anxiety, migraine headaches, pain and chemotherapy-induced nausea. Understanding how drugs bind to and regulate serotonin and opioid receptors will yield insights into designing novel medications for treating a large number of CNS diseases. |
| Rustioni, Aldo |
structure and cell biology of glutamate receptors and of actin-associated proteins |
Control of sensory input by presynapic glutamate receptors expressed by primary afferents to the spinal cord. The role of palladin, a newly discovered protein, in synaptic transmission and axonal sprouting in response to injury. |
| Samulski, Richard |
Adeno-associated virus, Gene Therapy, Gene Delivery, Muscle Delivery, Molecular Genetics, Molecular medicine, Viral vectors, disease models |
Development of efficient viral vectors for use in human gene therapy, testing adeno-associated virus (AAV) as a viral vector for gene delivery. Use of AAV vectors in animal models of human disease. |
| Sealock, Robert |
cytoskeleton; duchenne muscular dystrophy; dystrophin; membrane-cytoskeleton interaction; actin-binding proteins; protein chemistry; electron microscopy; freeze-etch; postsynaptic structure & cell biology |
Molecular mechanisms underlying acetylcholine receptor localization at neuromuscular junctions; the cytoskeleton of the muscle cell plasma membrane |
| Snider, William |
neurotrophins, growth factors, sensory neurons, axon growth, nociceptors, transgenic mice, spinal cord development |
Growth factor regulation of axonal morphology, Growth factor regulation of nociceptor development |
| Sockman, Keith |
auditory forebrain, behavior, birdsong, catecholamine, evolution, field biology, monoamine, neuroecology, neuroethology, reproduction |
Using songbirds as a study system, I take field and laboratory approaches to investigate the neural integration of ecological and social cues regulating life-history trade-offs and reproductive decisions such as mate-choice, courtship, reproductive timing, and reproductive effort. |
| Stuart, Ann |
visual system, synaptic transmission, histamine, biophysics |
Processing of visual information in a simple (invertebrate) nervous system; mechanisms of synaptic transmission from photoreceptors |
| Sulik, Kathleen |
craniofacial, fetal alcohol, autism |
Structural and molecular analyses of craniofacial abnormalities associated with fetal alcohol syndrome. |
| Suzuki, Kinuko |
Tay-Sachs disease, Sandhoff disease; Galactocerebroside, ganglioside, myelination, site-directed mutagenesis, molecular cloning; expression system |
Molecular biology of genetic neurological disorders |
| Thiele, Todd |
addiction, alcohol, behavior, electrophysiology |
My primary research interests are directed at the neurobiology of alcoholism. To study the central mechanisms involved with neurobiological responses to ethanol, I use both genetic and pharmacological manipulations. |
| Ting, Jenny |
neuroimmunology, genetics, neurodegeneration |
Regulation of transplantation genes in the CNS during neurodegenerative disease states |
| Valtschanoff, Juli |
neurotransmitter, spinal cord, somatosensory, nitric oxide, vanilloid, electron microscopy |
Dr. Valtschanoff's research interests are in neurotransmitters in the brain and spinal cord. Past studies have involved amino acid neurotransmitters and nitric oxide in the rat somatosensory system, combining immunocytochemical techniques at LM and EM level with tract tracing methods and models of altered neuronal activity. Recent reasearch has focused on glutamate receptors and their anchoring proteins, and the role of vanilloid receptors in the mediation of nociception in the dorsal horn of mammals. |
| Van Dyke, Terry |
genetics, cancer, glial, glioblastoma, transcription |
Regulatory mechanisms of cell-specific gene transcription and cell growth control |
Weinberg, Richard |
dendritic spines, calcium, neuroanatomy, electron microscopy, spinal cord, cortex, synaptic transmission, neurotransmitters, glutamate, GABA |
My primary research interest is postsynaptic mechanisms of glutamatergic transmission. I want to understand glutamatergic signaling, especially its short- and longterm modulation. My group is now studying the structural organization of the postsynaptic density and the dendritic spine. |
Weiss, Ellen |
vision, photoreceptors, kinases, cAMP |
Our laboratory is interested in the regulation of phototransduction in the vertebrate retina. We have been studying the phosphorylation of G protein-coupled receptor kinases by cAMP-dependent protein kinase and its novel role in light and dark adaptation. |
| Wightman, R |
neurotransmitters; dopamine, norepinephrine, 5-hydroxytryptamine; in vivo measurements |
Real-time electrochemical measurements of neurotransmitter secretion in the rat brain |
| Zylka, Mark |
GPCRs, Neural circuitry, electrophysiology, behavior, molecular neurobiology |
Molecules and Mechanisms for Pain |
