NBIO 722-723
(cross listed as PHYI and PHCO 722-723)
2011-2012 Schedule (PDF file)
Course Description (PDF file)
--------------------------------------------------------------------------------
BLOCK 1-METHODS TO STUDY THE BRAIN / ELECTRICAL SIGNALING (18 sessions) (NBIO 722A)
This first half of this block introduces such topics as brain cell biology, molecular biology applied to neurons, membrane potentials and imaging methods. The second half of this block introduces such topics as resistance, capacitance, passive membranes, classes of ion channels, potassium and calcium channels and action potential initiation. Fall. *Pevny, Hutton, Street, Ghuksyan, Robinson, Newbern, Brenman, Sealock and Manis.
BLOCK 2-NEUROTRANSMITTER RECEPTORS (10 sessions) (NBIO 722B)
This block covers such topics as cell and G Protein signaling, ligand binding, GABA-gated ion chanels, neurotransmitter receptor trafficking and dopamine release and receptors. Fall. *Manis, Brenman, Harden, Nicholas, Weiss, Robinson, Kash, Morrow and McElligott.
BLOCK 3-SYNAPTIC MECHANISMS AND INTRACELLULAR SIGNALING (10 sessions) (NBIO 722C)
This block introduces calcium signaling, electrophysiological analysis and molecular mechanisms of neurotransmitter release, synaptic plasticity and expression and maintenenace of LTP and LTD. Fall. *Philpot, CArelli, Kash, McCarthy, Wightman and Stuber.
BLOCK 4-DEVELOPMENT OF THE NERVOUS SYSTEM (11 sessions) (NBIO 723A)
This block covers neural induction, neural stem cells, glial development, neural cell death and neurotrophin during development and synaptic adhesion molecules. Spring. *Crews, Maness, Anton, Deshmukh and Pevny.
BLOCK 5-CNS: ANATOMY AND FUNCTION OF SENSORY AND MOTOR SYSTEMS (17 sessions) (NBIO 723B)
This block introduces the sensory pathways of vision, audition, taste, olfaction, pain, and touch, as well as the motor pathways of the spinal cord, basal ganglia, cerebellum, and motor cortex. Mechanisms of sensory information processing and motor execution are discussed. The section includes peripheral and central mechanisms of pain. Spring. *Zylka, Manis, Fitzpatrick, Philpot, Segal, Shoemaker and Weiss.
BLOCK 6-CNS: IMAGING AND DISEASE(12 sessions) (NBIO 723C)
This block covers CNS imaging, regeneration, and such diseases as Alzheimer's, ALS, Parkinson's, epilepsy, addiction, autism and schizophrenia. Spring. *Snider, Manis, Boettiger, Gilmore, Frohlich, McNamara, and Piven.
*denotes block head
