Anne Marion Taylor, PhD

Taylor

 

Assistant Professor

Research Description

Dysfunction at the synapse is a common theme in neurological disease and following traumatic brain injury (TBI). Our lab focuses on examining changes that occur at mammalian synapses during development, with disease, and following TBI. We exploit micro-scale technology and microfluidics to overcome traditional challenges in working with cultured neurons. Our novel approaches are particularly relevant given the emerging use of human induced pluripotent stem cells (iPSCs) to model disease. Human iPSCs are stem cells derived from patients’ skin cells that can be generated into functional neurons and then studied in culture; this model system allows us to investigate how human synapses are altered in disease. We use devices that allow access to distinct cellular compartments to investigate localized changes at synapses and signaling from synapse-to-nucleus. We also exploit the scalability of these approaches—a unique advantage given low-throughput approaches of traditional techniques in neuroscience.

Selected Publications

Taylor, A.M.*, Wu, J.R., Tai, H.C. & Schuman, E.M.* Axonal translation of β-catenin regulates synaptic vesicle dynamics. J Neurosci, 2013. 33(13): 5584-9. PMID: 23536073 *co-corresponding authors

**highlighted in “This Week in the Journal”

Taylor, A.M., Dieterich, D.C., Ito, H. T., Kim, S.A. & Schuman, E.M. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron, 2010. 66, 57-68, PMID: 20399729

Taylor, A.M. & Jeon, N.L. Micro-scale and microfluidic devices for neurobiology. Curr Opin Neurobiol, 2010. 20(5), 640-7. PMID: 20739175

Taylor, A.M., Berchtold, N.C., Perreau, V.M., Tu, C.H., Jeon, N.L. & Cotman, C.W.  Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci, 2009. 29: p. 4697-4707. PMID: 19369540

**highlighted in “This Week in the Journal”

Taylor, A.M., M. Blurton-Jones, S.W. Rhee, D.H. Cribbs, C.W. Cotman, and N.L. Jeon, A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods, 2005. 2(8): p. 599-605. PMID: 16094385

** cover illustration


Contact Information

Email
www.unc.edu/~amt

Office: (919) 843-8156
Lab: (919) 843-9324


Affiliations