We are interested in how neurons, and the circuits they form, compute. We are currently focused on primary and higher visual areas in the mouse. We explore this neocortical circuitry-- its development and function-- using imaging, electrophysiology, and behavior. We hope to gain insight into how the brain processes sensory stimuli and generates appropriate behavioral responses. We also hope to illuminate the mechanisms in complex diseases like autism and schizophrenia, and suggest new therapeutic strategies.
Our lab also uses neuroengineering approaches to develop novel instrumentation to enable previously impossible neuroscience experiments. Recently, we have developed multiphoton imaging systems that can image subcellular calcium dynamics across large brain volumes.ular, cellular, and synaptic mechanisms underlie the function of large-scale neocortical circuitry. Ultimately, we hope this better understanding may illuminate the mechanisms in complex diseases like autism and schizophrenia, and suggest new therapeutic strategies.
Office: (919) 966-2349