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Research Areas: Synaptic Structure and Function


Name Keywords Research Interests
Bhat, Manzoor Axon, Node of Ranvier, glia, drosophila, mice, neurexin Genetic Dissection of Axon-Glial Interactions in Drosophila and Mice
Brenman, Jay neurodevelopment, dendrites, axons, molecular genetics, GFP Molecular genetics to identify genes required for dendrite formation and neurodevelopment using Drosophila.
Carelli, Regina electrophysiology, electrochemistry, dopamine, drug abuse, motivated behaviors, cocaine self-administration Neurophysiological mechanisms of goal-directed behaviors; role of nucleus accumbens plasticity in cocaine abuse.
Hodge, Clyde drug addiction, pharmacology, behavior, neural circuits, genetics, receptors Behavioral neurobiology and pharmacogenomics of drug abuse: Neural circuits and genes that mediate drug, self-administration and discrimination.
Mailman, Richard dopamine receptors, Parkinson's disease, Schizophrenia, molecular modeling, cAMP, second messengers Neurobiology of dopamine receptors
Manis, Paul synaptic transmission, receptors, ion channels, potassium channels, spike-timing dependent plasticity, patch clamp, brain slice, single cell neural modeling, calcium imaging, quantitative real-time PCR, single cell PCR Cellular mechanisms of auditory information processing and plasticity. Studies examine ion channels and synaptic function and plasticity in the brainstem and cortex.
McCarthy, Kenneth glial cells, calcium signaling Regulation of intracellular calcium and glial cell function by neurotransmitter action; regulation of glial cell phenotype
Meeker, Rick neuroendocrine; supraoptic nucleus; pituitary; HIV; vasopressin; in situ hybridization; cholinergic receptors; AIDS dementia Immunocytochemistry and electrophysiology of vasopressin neuroendocrine cells of the hypothalamus
Morrow, A Leslie GABA-A receptor, mRNA regulation, ethanol, barbiturates, benzodiazepines, neuroactive steroids Molecular Neuropharmacology, Mechanisms of Receptor Regulation, Alcohol Research, GABA-A Receptors
Nicholas, Robert receptors, purinergic receptors, G-proteins Regulation and function of G-protein coupled receptors in the CNS
Otey, Carol cytoskeleton, growth cone motility, astrocyte activation, glial scar, presynaptic plasticity, vesicle trafficking Regulation of actin cytoskeleton organization and its role in axonal outgrowth during development and after injury; changes in astrocyte morphology and motility in response to injury of the CNS.
Perl, Edward pain, nocioception, brain slices, spinal cord, sensory processing Specificity of sensory systems; cellular and molecular correlates of nociceptive function in mammals
Philpot, Benjamin synaptic plasticity, visual system, ocular dominance, LTP, LTD, NMDA receptors, cortex We are studying how visual experience modifies the properties of synaptic plasticity (LTP and LTD) so that the visual world can be properly analyzed. We use brain slice preparations from transgenic mice. These studies will characterize how experience regulates the elementary properties of plasticity and excitatory synaptic transmission.
Robinson, Donita alcoholism, electrophysiology, electrochemistry, behavior, neuropharmacology, neural circuits, dopamine, alcohol self-administration, drug addiction Cellular mechanisms underlying alcohol use in an animal model of alcohol self-administration: electrophysiological recordings at multielectrode arrays; electrochemical measurements of dopamine at microelectrodes; neuroadaptations induced by chronic alcohol exposure; pharmacotherapy for alcoholism.
Rosenberg, Robert electrophysiology; ion channels; patch clamp; Xenopus oocytes; ionotropic receptors Molecular mechanisms of gating and ion permeation of nicotinic acetylcholine receptors
Rustioni, Aldo structure and cell biology of glutamate receptors and of actin-associated proteins Control of sensory input by presynapic glutamate receptors expressed by primary afferents to the spinal cord. The role of palladin, a newly discovered protein, in synaptic transmission and axonal sprouting in response to injury.
Sealock, Robert cytoskeleton; duchenne muscular dystrophy; dystrophin; membrane-cytoskeleton interaction; actin-binding proteins; protein chemistry; electron microscopy; freeze-etch; postsynaptic structure & cell biology Molecular mechanisms underlying acetylcholine receptor localization at neuromuscular junctions; the cytoskeleton of the muscle cell plasma membrane
Valtschanoff, Juli neurotransmitter, spinal cord, somatosensory, nitric oxide, vanilloid, electron microscopy Dr. Valtschanoff's research interests are in neurotransmitters in the brain and spinal cord. Past studies have involved amino acid neurotransmitters and nitric oxide in the rat somatosensory system, combining immunocytochemical techniques at LM and EM level with tract tracing methods and models of altered neuronal activity. Recent reasearch has focused on glutamate receptors and their anchoring proteins, and the role of vanilloid receptors in the mediation of nociception in the dorsal horn of mammals.
Weinberg, Richard dendritic spines, calcium, neuroanatomy, electron microscopy, spinal cord, cortex, synaptic transmission, neurotransmitters, glutamate, GABA My primary research interest is postsynaptic mechanisms of glutamatergic transmission. I want to understand glutamatergic signaling, especially its short- and longterm modulation. My group is now studying the structural organization of the postsynaptic density and the dendritic spine.
Wightman, R neurotransmitters; dopamine, norepinephrine, 5-hydroxytryptamine; in vivo measurements Real-time electrochemical measurements of neurotransmitter secretion in the rat brain
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