I graduated from Indiana Purdue in 2005, where I received my Bachelor of Science degree.
Alcoholism is the most costly public health problem in the world, and effective treatments are needed to help those suffering from this devastating disease. My studies will explore whether increasing neuroactive steroids in specific brain sites will alter alcohol self-administration and anxiety-like behavior in a rat model of excessive drinking. Brain steroidogenesis will be increased by viral-vector-mediated gene delivery of the biosynthetic enzyme that produces pregnenolone from cholesterol. We predict this will reduce alcohol self-administration, anxiety-like behavior and relapse drinking. This work may lead to an effective therapeutic strategy for alcoholism.