Services

Several sub-specialty clinics exist to address the needs of patients with neuromuscular disease.

The Dystrophinopathy Team

The Dystrophinopathy Team is a multidisciplinary program involving members of the Department of Neurology (Drs. Howard, Weig, Fan), the Gene Therapy Center (Dr. Samulski), the Division of Molecular Pharmaceutics (Dr. Xiao) of the School of Pharmacy, the Magnetic Resonance Imaging Research Center (Dr. Lin) of the Department of Radiology and the Canine Laboratory Facility (Dr. Kornegay) of the Department of Pathology and Laboratory Medicine. The mission of this group is to develop clinical gene therapy trials for the treatment of Duchenne muscular dystrophy and to identify surrogate markers that can be used to assess changes in disease severity during these trials.

The Muscular Dystrophy Association Clinic

The Muscular Dystrophy Association Clinic sponsored by the Muscular Dystrophy Association meets several times weekly and is under the direction of James F. Howard, Jr., M.D. and Spencer G. Weig, M.D. These clinics provide adults and children with a variety of neuromuscular diseases comprehensive diagnostic evaluation, consultation, treatment and management. Some of the diseases followed in this clinic include muscular dystrophy in adults and children (Duchenne's, Becker’s, Myotonic, Limb-Girdle, FSH), inflammatory myopathies (polymyositis, dermatomyositis, inclusion body myositis), metabolic and mitochondrial myopathies, disease of neuromuscular transmission (Myasthenia Gravis, Lambert-Eaton syndrome), congenital myopathies, hereditary peripheral neuropathies (Charcot-Marie-Tooth disease), and motor neuron disease (Amyotrophic Lateral Sclerosis [ALS], spinal muscular atrophy [SMA])

The Myasthenia Gravis Clinic

The Myasthenia Gravis is under the direction of James F. Howard, Jr., M.D. The Myasthenia Gravis Clinic offers comprehensive diagnostic evaluation, consultation, treatment and management for patients with myasthenia gravis from around the world. Dr. Howard also carries out clinical and laboratory-based research on the causes, diagnosis and treatment of myasthenia gravis. In addition to providing personal, expert care to patients, he serves as an advisor to national organizations interested in myasthenia gravis, including the Myasthenia Gravis Foundation of America and the Muscular Dystrophy Association.

The Myopathy Clinic

The Myopathy Clinic provides for the comprehensive diagnostic evaluation, consultation, treatment and management of patients with a variety of muscle disorders. Some of the diseases followed in this clinic include muscular dystrophies, metabolic and toxic myopathies and inflammatory myopathies.

The Peripheral Neuropathy Clinic

The Peripheral Neuropathy Clinic provides for the comprehensive diagnostic evaluation, consultation, treatment and management of patients with a variety of peripheral neuropathies. Some of the diseases followed in this clinic include hereditary neuropathies (such as Charcot-Marie-Tooth Disease), diabetic neuropathy, amyloid neuropathy, chronic inflammatory demyelinating neuropathy (CIDP), small fiber sensory neuropathies and vasculitic neuropathies.

The Clinical Neurophysiology (CNP) Laboratory

The Clinical Neurophysiology Laboratory at UNC Hospitals is a multi-disciplinary laboratory providing state of the art expertise in the diagnostic evaluation and physiological characterization of all nervous system disorders. Several Sections are present within the laboratory. The Neuromuscular Section performs Autonomic Function studies, EMG-NCS (electromyography-nerve conduction studies), neurography, quantitative EMG studies, single fiber EMG and Quantitative Sensory Testing. Approximately 1600 patient studies are performed yearly. In addition, other sections of the CNP Laboratory provide expertise in EEG (electroencephalography), video-EEG and ambulatory EEG monitoring, evoked potential studies and sleep studies.