Anton Lab identifies a mechanism underlying distinct patterns of neuronal migration in the developing cerebral cortex

In a Developmental Cell paper, Anton lab shows that APC-regulated microtubule severing is necessary for appropriate patterns of neuronal migration and placement in the developing brain.

Anton Lab identifies a mechanism underlying distinct patterns of neuronal migration in the developing cerebral cortex click to enlarge Eva Anton, PhD

Coordinated pattern of interneuron and projection neuron migration is a process fundamental to the formation of cortical neuronal circuitry. In a Developmental Cell paper, they show that APC-regulated microtubule severing, via p60-katanin, promotes branching intensive interneuron migration, but not glial-guided radial migration of projection neurons. This study provides new perspectives on why human mutations in APC and KATANIN cause brain malformations.

 

To read the full paper, click here.