The study shows how a class of commonly used fungicides, designed to protect crops, can cause gene expression changes in mouse brain cells that look strikingly similar to changes in the brains of people with autism and Alzheimer’s disease.
Spencer Smith was awarded a Human Frontier Science Program grant for the "real-time tracking and imaging of neuronal dynamics in freely moving vertebrates.
Jason Yi, PhD, a postdoc in the Zylka lab was selected as a finalist for the SFARI Bridge to Independence Award for his proposed research project, "Inhibitory circuit dysfunction in autism spectrum disorder".
In a paper published in Nature Communications, Janet Berrios, a graduate student in the Philpot lab, discovered that the loss of UBE3A decreases the release of the GABA neurotransmitter and alters reward-seeking behavior in an important neural pathway once presumed to be principally regulated by the dopamine neurotransmitter.
The UNC School of Medicine has awarded the 16th Perl-UNC Prize to Christopher A. Walsh, MD, PhD, Chief of the Division of Genetics and Genomics at Boston Children’s Hospital and Bullard Professor of Pediatrics and Neurology at Harvard Medical School, for the “discovery of genes and mechanisms regulating human cortical development.”
Garret Stuber publishes new review in Nature Neuroscience on the neurocircuitry of the lateral hypothalamus for feeding and reward related behaviors.
Mark Zylka, PhD, will serve as director and Ben Philpot, PhD, will serve as associate director of the UNC Neuroscience Center at the UNC School of Medicine, effective July 1. William Snider, MD, who has served as the center’s director for nearly 17 years, will step down from his leadership role, but will remain on faculty as professor of neurology, while also continuing his research.
Deshmukh lab discovers a novel role of Dicer in the rapidly dividing cells of the developing brain and brain tumors
In a paper published in Cell Reports, Vijay Swahari, a postdoctoral fellow in Deshmukh lab, identifies how the critical role of Dicer in DNA damage response can be exploited for therapy in aggressive brain tumors like Medulloblastoma.
In the article published in Developmental Cell, Stephanie Gupton's lab shows that the E3 ligase TRIM9 ubiquitinates the actin polymerase VASP, altering VASP tip localization and dynamics and reducing filopodial stability and density.
Spencer Smith developed a new microscope which can simultaneously view individual neurons firing in two or more brain regions of a moving laboratory animal, enabling researchers to see how different areas of the brain work together to process information.
Deshmukh lab discovers the role of a neuronal stress pathway in triggering Herpes Simplex Virus (HSV) reactivation
In a paper published in Cell Host and Microbe, Anna Cliffe, a postdoctoral fellow in Deshmukh lab, identifies how activation of JNK in response to neuronal stress triggers changes to the HSV chromatin and reactivation from latency.
Bryan Roth describes a new tool to probe the activity of orphan receptors in the brain in the journal Nature
In an article published in Nature, Bryan Roth describes a new tool to probe the activity of orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery.
The 16th Annual UNC Neuroscience Symposium was held on October 8th at the Carolina Club. Attendees from the UNC Neuroscience community enjoyed a breakfast reception with the speakers, Joseph G. Gleeson, Yang Dan and Alcino Silva, three riveting talks followed by question-and-answer sessions, and a buffet luncheon at the conclusion.
Garret Stuber, PhD, was awarded the 2015 Gill Transformative Investigator Award from Indiana University for his contributions to cellular and molecular neuroscience. He was presented the award and prize at the annual Gill Symposium at the Linda and Jack Gill Center for Biomolecular Science.
In an article published in the journal Cell, Zylka lab shows how a genetic mutation disables a regulatory molecular switch, creating an enzyme that cannot be turned off and leading to abnormal brain development and autism.
Spencer Smith, PhD, has been awarded the 2015 McKnight Technological Innovations in Neuroscience Award. He will receive $200,000 over two years to expand the range of technologies for studying the brain and its diseases and to make new technologies available to the field of neuroscience.
Rett Syndrome Research Trust has awarded Mark Zylka $400,000 to screen for other compounds of topoisomerase inhibitors that can rebalance expression of long genes safely.
Spencer Smith discussed how new technologies and multidisciplinary research are advancing our understanding of the brain at a congressional briefing organized by the House Appropriations Subcommittee on Commerce, Justice and Science and National Science Foundation on Thursday, July 9th.
Dr. Jason Stein from UCLA will join the faculty of the Neuroscience Center and the Department of Genetics in January 2016.
Jeffrey Stirman, Ph.D., was just awarded a grant of $500,000 as part of the Burroughs Wellcome Fund’s Career Awards at the Scientific Interface (CASI) program.
Lei Xing of received a two-year Young Investigator Award from Children’s Tumor Foundation. Lei Xing is a Research Scientist in Dr. William Snider’s lab. He proposes to investigate the effect of ERK/MAPK hyperactivation on neural circuit development.
Using a weak electric current to alter a specific brain activity pattern, Frohlich lab increased creativity in healthy adults. Now they’re testing the same experimental protocol to alleviate symptoms in people with depression.
The 15th Perl/UNC Neuroscience Prize award ceremony and lecture was held on Thursday, May 14th at 3PM in G202 MBRB.
Using a new ‘chemogenetic’ technique invented by Bryan Roth’s lab at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.
Spencer Smith, PhD, assistant professor of cell biology and physiology and member of the UNC Neuroscience Center, was featured on North Carolina Now, a nightly program on UNC TV.