Our goal is to understand cortical network dynamics and to become a key contributor to the fields of network neuroscience and brain stimulation. We combine electrophysiology, computational modeling, and engineering principles to investigate how cortical networks generate physiological and pathological activity states and how perturbations can be used to modulate these states. We aim for a rapid translation of our research into the clinical domain for treatment of patients with psychiatric and neurological disorders. We strive to make our laboratory a productive, collaborative, and happy workplace.
We currently work in the two following areas:
(1) Network oscillations, cortical states, and sensory processing.
Oscillations represent fundamental activity states both in physiological and pathological conditions in cortex. We study how cortex generates these activity states and how sensory input modulates cortical oscillations in the awake and anesthetized animal. We combine multichannel electrophysiological recordings with advanced data processing methods and computational modeling to unravel the dynamic landscape of cortical activity states.
(2) Non-invasive brain stimulation.
We develop novel brain stimulation paradigms to enhance and modulate the oscillation structure of cortical network activity. We use computer simulations and in vitro recordings to prototype stimulation paradigms that we then subsequently test in animals and humans.
Ali MM, Sellers KK, Fröhlich F. Transcranial alternating current stimulation modulates large-scale cortical network activity by network resonance. J Neurosci. 2013 Jul 3;33(27):11262-75. PMID: 23825429
Schmidt SL, Chew EY, Bennett DV, Hammad MA, Fröhlich F. Differential effects of cholinergic and noradrenergic neuromodulation on spontaneous cortical network dynamics. Neuropharmacology. 2013 Sep;72:259-73. PMID: 23643755
F Frohlich, TJ Sejnowski, M Bazhenov. Network bistability mediates spontaneous transitions between normal and pathological brain states. J. Neurosci. 2010 Aug 11;30(32):10734-43. PMID: 20702704
F Frohlich and DA McCormick. Endogenous Electric Fields May Guide Neocortical Network Activity. Neuron. 2010 July; 67(1):129-143. PMID: 20624597
Nita DA, Cissé Y, Frohlich F, Timofeev I. Cortical and thalamic components of neocortical kindling-induced epileptogenesis in behaving cats. Exp. Neurol. 2008 June; 211(2):518-28. PMID: 18423621
Frohlich F, Bazhenov M, Sejnowski TJ. Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. J. Neurosci. 2008 Feb 13;28(7):1709-20. PMID: 18272691
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