Investigate the influence of the cannabinoid receptor system on depression-like behavior. Analyze behavioral responses, such as time spent immobile in the forced swim test (FST) and locmotor activity, to stress and cannabinoid receptor ligand modifiers including AM404, anandamide reuptake inhibitor, and URB597, anandamide metabolism inhibitor. Determine changes in corticosterone release in response to pharmacological manipulation of the cannabinoid receptor system and stress