Eric Scott

Eric Scott
Undergraduate Institution:

University of North Carolina at Pembroke

Department: Microbiology & Immunology
PI: Stephen Clarke
Research Summary: Over the last twenty years, the Clarke lab focus has been on the lost of immune tolerance and how it ultimately lead to autoimmune diseases, in particular systemic lupus erythematosus (SLE). I am interested in a subset of B cells that is over expanded in SLE patients. This subset of B cells is characterized by the increased expression of CD19, a BCR co-receptor that augments the signals of the B cell receptor. My project goal is to determine the percentage of B cells within this subset that are autoreactive and linked this subset to the development of more severe lupus. Our long-term goal is to use our research to improve therapeutic treatments for patients suffering with SLE.