|Undergraduate Institution:||University of Washington|
|Department:||Genetics & Molecular Biology|
Ewing Sarcoma is the second most common bone and soft tissue malignancy affecting pediatric patients. My project utilizes moleucular biology and bioinformatics to understand the chromatin and histone modifications that take place during transformation. Specifically, I am investigating how a chimeric oncoprotein, EWS-FLI, alters the chromatin landscape within the mesenchymal stem cell, the putative cell of origin for Ewing Sarcoma. I am interested in identifying the features present within the stem cell's chromatin that allows the chimeric oncoprotein to function aberrantly.