Bachelor's: University of North Carolina at Chapel Hill
Post Bacc: Virginia Tech
The Nackley Lab incorporates molecular, genetic and behavioral approaches to discover signaling mechanisms that drive persistent pain conditions. My project encompasses this theme in an effort to explore the underlying mechanisms that drive opioid-induced hyperalgesia (OIH). We hypothesize that MOR-1K, a splice variant of the mu opioid receptor, contributes to the development of OIH. I will utilize molecular techniques to examine the role genetic variants may play in MOR-1K gene expression and OIH development. I will also utilize behavioral techniques to examine and manipulate rodent pain responses.