|Undergraduate Institution:||North Carolina Central University|
The manifestation of the metabolic syndrome is increasing in prevalence in the world with chronic consequences, including cardiovascular abnormalities and diabetes. Conventional risk factors, such as a high fat diet and a sedentary lifestyle have been considered major contributors of the metabolic syndrome. Recently, it has been postulated that air pollution may induce insulin resistance by initiating endoplasmic reticulum stress and altering metabolic processes in the liver, an important metabolic organ involved in glucose homeostasis, but the mechanisms remained to be elucidated. Particularly, it is not understood how pulmonary encountered pollutants, ozone may induce a systemic metabolic stress and more importantly contribute to diabetes, obesity and cardiovascular diseases. I am currently studying the potential mechanism of ozone-induced metabolic effects in rodents models to better understand if these effects can occur in human and may also lead to type II diabetes or other cardiovascular effects long term .