Reginald Cannady Ph.D.

Reginald Cannady
Undergraduate Institution:

Fayetteville State University

Department: Neurobiology
PI: Clyde Hodge
Research Summary: Alcoholism is a disease and a major public health issue in the United States. Evidence suggests that escalated alcohol abuse is due to dysfunction of components of the central nervous system that mediate reward. My research focuses on determining the molecular substrates, neurobiological signaling pathways, and neuronal circuitry that mediate the reinforcing effects of alcohol. Specifically, I am investigating the role of multiple glutamate receptor subtypes in mediating alcohol reinforcement as well as the discriminative stimulus or “subjective” effects of alcohol. We have evidence that suggests that α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors may be involved in escalated voluntary alcohol consumption using an operant self-administration paradigm. Further investigation of this phenomenon may lead to a greater understanding of the etiology of alcoholism as well as novel pathways that may serve as therapeutic targets to treat alcohol abuse disorders.