Publications

UNC PREP Scholars are highly productive members of the UNC biomedical research community. Below are some of the most recent publications with contributions from our Scholars.

Relevant Publications by UNC PREP Leadership

1: Hall JD, O'Connell AB, Cook JG. Predictors of Student Productivity in Biomedical Graduate School Applications. PLoS One. 2017 Jan 11;12(1):e0169121. doi: 10.1371/journal.pone.0169121. PubMed PMID: 28076439.

2: Hall JD, Harrell JR, Cohen KW, Miller VL, Phelps PV, Cook JG. Preparing Postbaccalaureates for Entry and Success in Biomedical PhD Programs. CBE Life Sci Educ. 2016 fall;15(3). pii: ar27. doi: 10.1187/cbe.16-01-0054. PubMed PMID:27496358; PubMed Central PMCID: PMC5008874.

3: Layton RL, Brandt PD, Freeman AM, Harrell JR, Hall JD, Sinche M. Diversity Exiting the Academy: Influential Factors for the Career Choice of Well-Represented and Underrepresented Minority Scientists. CBE Life Sci Educ. 2016 fall;15(3). pii: ar41. doi: 10.1187/cbe.16-01-0066. PubMed PMID: 27587854; PubMed Central PMCID: PMC5008888.

UNC PREP Scholar Publications (scholars in BOLD)

1: Martinez-Rodriguez L, Erdogan O, Jimenez-Rodriguez M, Gonzalez-Rivera K, Williams T, Li L, Weinreb V, Collier M, Chandrasekaran SN, Ambroggio X, Kuhlman B, Carter CW Jr. Functional Class I and II amino acid activating enzymes can be coded by opposite strands of the same gene. J Biol Chem. 2016 Nov 4;291(45):23830-23831. PubMed PMID: 27815453; PubMed Central PMCID: PMC5095434.

2: Powell SK, Khan N, Parker CL, Samulski RJ, Matsushima G, Gray SJ, McCown TJ. Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism. Gene Ther. 2016 Nov;23(11):807-814. doi:10.1038/gt.2016.62. PubMed PMID: 27628693.

3: Knowlin L, Stanford L, Cairns B, Charles A. The effect of smoking status on burn inhalation injury mortality. Burns. 2016 Oct 1. pii: S0305-4179(16)30352-7.  doi: 10.1016/j.burns.2016.09.003. [Epub ahead of print] PubMed PMID: 27707642.

4: Knowlin L, Stanford L, Moore D, Cairns B, Charles A. The measured effect magnitude of co-morbidities on burn injury mortality. Burns. 2016 Nov;42(7):1433-1438. doi: 10.1016/j.burns.2016.03.007. PubMed PMID: 27593340.

5: Henry CE, Wang YY, Yang Q, Hoang T, Chattopadhyay S, Hoen T, Ensign LM, Nunn KL, Schroeder H, McCallen J, Moench T, Cone R, Roffler SR, Lai SK. Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus. Acta Biomater. 2016 Oct 1;43:61-70. doi: 10.1016/j.actbio.2016.07.019. PubMed PMID: 27424083.

6: Wang YY, Schroeder HA, Nunn KL, Woods K, Anderson DJ, Lai SK, Cone RA. Diffusion of Immunoglobulin G in Shed Vaginal Epithelial Cells and in Cell-Free Regions of Human Cervicovaginal Mucus. PLoS One. 2016 Jun 30;11(6):e0158338. doi:10.1371/journal.pone.0158338. PubMed PMID: 27362256; PubMed Central PMCID: PMC4928780.

7: Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount  C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K. Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology. Neuron. 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038. PubMed PMID: 27346529; PubMed Central PMCID: PMC4986697.

8: Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, Duffney LJ, Kumar S, Mague  SD, Hulbert SW, Dutta N, Hayrapetyan V, Yu C, Gaidis E, Zhao S, Ding JD, Xu Q, Chung L, Rodriguiz RM, Wang F, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H, Jiang YH. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun. 2016 May 10;7:11459. doi: 10.1038/ncomms11459. PubMed PMID: 27161151; PubMed Central PMCID: PMC4866051.

9: Lange EM, Ribado JV, Zuhlke KA, Johnson AM, Keele GR, Li J, Wang Y, Duan Q, Li G, Gao Z, Li Y, Xu J, Zheng SL, Cooney KA. Assessing the Cumulative Contribution  of New and Established Common Genetic Risk Factors to Early-Onset Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):766-72. doi:10.1158/1055-9965.EPI-14-0995. PubMed PMID: 26671023; PubMed Central PMCID: PMC4873425.

10: Hirsch ML, Wolf SJ, Samulski RJ. Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors. Methods Mol Biol. 2016;1382:21-39. doi: 10.1007/978-1-4939-3271-9_2. PubMed PMID: 26611576; PubMed Central PMCID: PMC4971574.

11: Wang YY, Nunn KL, Harit D, McKinley SA, Lai SK. Minimizing biases associated with tracking analysis of submicron particles in heterogeneous biological fluids. J Control Release. 2015 Dec 28;220(Pt A):37-43. doi10.1016/j.jconrel.2015.10.021. PubMed PMID: 26478013; PubMed Central PMCID: PMC4688199.

12: Nunn KL, Wang YY, Harit D, Humphrys MS, Ma B, Cone R, Ravel J, Lai SK. Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota. MBio. 2015 Oct 6;6(5):e01084-15. doi: 10.1128/mBio.01084-15. PubMed PMID: 26443453; PubMed Central PMCID: PMC4611035.

13: Martinez-Rodriguez L, Erdogan O, Jimenez-Rodriguez M, Gonzalez-Rivera K, Williams T, Li L, Weinreb V, Collier M, Chandrasekaran SN, Ambroggio X, Kuhlman B, Carter CW Jr. Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene. J Biol Chem. 2015 Aug7;290(32):19710-25. doi: 10.1074/jbc.M115.642876. Erratum in: J Biol Chem. 2016 Nov 4;291(45):23830-23831. PubMed PMID: 26088142; PubMed Central PMCID: PMC4528134.

14: Immormino RM, Starbird CA, Silversmith RE, Bourret RB. Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases. Biochemistry. 2015 Jun 9;54(22):3514-27. doi: 10.1021/acs.biochem.5b00286. PubMed PMID: 25928369; PubMed Central PMCID: PMC4516285.

15: Goodrich LR, Grieger JC, Phillips JN, Khan N, Gray SJ, McIlwraith CW, Samulski RJ. scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy. Gene Ther. 2015 Jul;22(7):536-45. doi: 10.1038/gt.2015.21. PubMed PMID: 25902762.

16: Powell SK, Rivera-Soto R, Gray SJ. Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy. Discov Med.  2015 Jan;19(102):49-57. Review. PubMed PMID: 25636961; PubMed Central PMCID: PMC4505817.

17: Kantor B, Bailey RM, Wimberly K, Kalburgi SN, Gray SJ. Methods for gene transfer to the central nervous system. Adv Genet. 2014;87:125-97. doi: 10.1016/B978-0-12-800149-3.00003-2. Review. PubMed PMID: 25311922; PubMed Central PMCID: PMC4519829.

18: Kumar S, Hultman R, Hughes D, Michel N, Katz BM, Dzirasa K. Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress. Nat Commun. 2014 Jul 29;5:4537. doi: 10.1038/ncomms5537. PubMed PMID: 25072279; PubMed Central PMCID: PMC4148151.

19: Carter CW Jr, Li L, Weinreb V, Collier M, Gonzalez-Rivera K, Jimenez-Rodriguez M, Erdogan O, Kuhlman B, Ambroggio X, Williams T, Chandrasekharan SN. The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed. Biol Direct. 2014 Jun 14;9:11. doi: 10.1186/1745-6150-9-11. PubMed PMID: 24927791; PubMed Central PMCID: PMC4082485.

20: Noah TL, Zhang H, Zhou H, Glista-Baker E, Müller L, Bauer RN, Meyer M, Murphy PC, Jones S, Letang B, Robinette C, Jaspers I. Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study. PLoS One. 2014 Jun 9;9(6):e98671. doi: 10.1371/journal.pone.0098671. Erratum in: PLoS One. 2014;9(9):e109513. PubMed PMID: 24910991; PubMed Central PMCID: PMC4049587.

21: Lange EM, Johnson AM, Wang Y, Zuhlke KA, Lu Y, Ribado JV, Keele GR, Li J, Duan Q, Li G, Gao Z, Li Y, Xu J, Isaacs WB, Zheng S, Cooney KA. Genome-wide association scan for variants associated with early-onset prostate cancer. PLoS One. 2014 Apr 16;9(4):e93436. doi: 10.1371/journal.pone.0093436. PubMed PMID: 24740154; PubMed Central PMCID: PMC3989171.

22: Wang YY, Kannan A, Nunn KL, Murphy MA, Subramani DB, Moench T, Cone R, Lai SK. IgG in cervicovaginal mucus traps HSV and prevents vaginal herpes infections. Mucosal Immunol. 2014 Sep;7(5):1036-44. doi: 10.1038/mi.2013.120. PubMed PMID: 24496316; PubMed Central PMCID: PMC4122653.

23: Meyer M, Bauer RN, Letang BD, Brighton L, Thompson E, Simmen RC, Bonner J, Jaspers I. Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L269-76.  doi: 10.1152/ajplung.00290.2013. PubMed PMID: 24285265; PubMed Central PMCID: PMC3920198.

24: Judson MC, Sosa-Pagan JO, Del Cid WA, Han JE, Philpot BD. Allelic specificity of Ube3a expression in the mouse brain during postnatal development. J Comp Neurol. 2014 Jun 1;522(8):1874-96. doi: 10.1002/cne.23507. PubMed PMID: 24254964; PubMed Central PMCID: PMC3984624.

25: Cheng Y, Johnson MD, Burillo-Kirch C, Mocny JC, Anderson JE, Garrett CK, Redinbo MR, Thomas CE. Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation. Infect Immun. 2013 Nov;81(11):4280-9. doi: 10.1128/IAI.00493-13. PubMed PMID: 24002068; PubMed Central PMCID: PMC3811810.

26: Hayden JD, Brown LR, Gunawardena HP, Perkowski EF, Chen X, Braunstein M. Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis. Microbiology. 2013 Sep;159(Pt 9):1986-99. doi:10.1099/mic.0.068585-0. PubMed PMID: 23813678; PubMed Central PMCID: PMC3783017.

27: Walker KA, Maltez VI, Hall JD, Vitko NP, Miller VL. A phenotype at last: essential role for the Yersinia enterocolitica Ysa type III secretion system in a Drosophila melanogaster S2 cell model. Infect Immun. 2013 Jul;81(7):2478-87. doi:10.1128/IAI.01454-12. PubMed PMID: 23630961; PubMed Central PMCID: PMC3697602.

28: Nagabhushan Kalburgi S, Khan NN, Gray SJ. Recent gene therapy advancements for neurological diseases. Discov Med. 2013 Feb;15(81):111-9. Review. PubMed PMID: 23449113.

29: Crooke AK, Fuller JR, Obrist MW, Tomkovich SE, Vitko NP, Richardson AR. CcpA-independent glucose regulation of lactate dehydrogenase 1 in Staphylococcus  aureus. PLoS One. 2013;8(1):e54293. doi: 10.1371/journal.pone.0054293. PubMed PMID: 23342123; PubMed Central PMCID: PMC3544828.

30: Kumar S, Black SJ, Hultman R, Szabo ST, DeMaio KD, Du J, Katz BM, Feng G, Covington HE 3rd, Dzirasa K. Cortical control of affective networks. J Neurosci. 2013 Jan 16;33(3):1116-29. doi: 10.1523/JNEUROSCI.0092-12.2013. PubMed PMID: 23325249; PubMed Central PMCID: PMC3711588.

31: Porsch EA, Johnson MD, Broadnax AD, Garrett CK, Redinbo MR, St Geme JW 3rd. Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility.  J Bacteriol. 2013 Feb;195(4):886-95. doi: 10.1128/JB.02186-12. PubMed PMID: 23243304; PubMed Central PMCID: PMC3562114.

32: Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 2012 Nov;19(11):1155-60. doi: 10.1038/nsmb.2391. PubMed PMID: 23022729; PubMed Central PMCID: PMC3492551.

33: Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR. Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner. PLoS One. 2011;6(12):e29629. doi: 10.1371/journal.pone.0029629. PubMed PMID: 22242136; PubMed Central PMCID: PMC3248442.

34: Sparrow AM, Lowery-Gionta EG, Pleil KE, Li C, Sprow GM, Cox BR, Rinker JA, Jijon AM, Peňa J, Navarro M, Kash TL, Thiele TE. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 2012 May;37(6):1409-21. doi: 10.1038/npp.2011.327. PubMed PMID: 22218088; PubMed Central PMCID: PMC3327846.

35: Pleil KE, Lopez A, McCall N, Jijon AM, Bravo JP, Kash TL. Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 2012 Mar;62(4):1777-86. doi:10.1016/j.neuropharm.2011.12.002. PubMed PMID: 22182779; PubMed Central PMCID:PMC3269561.