Reciprocal Regulation of Acute and Chronic Virulence Factor Expression in Pseudomonas aeruginosa During Cystic Fibrosis Airway Infection

 

Trainee:

Kimberly Coggan

Coggan

Research Mentor:

Dr. Matthew Wolfgang, PhD

Wolfgang

Clinical Co-Mentor;

Dr. Richard Boucher, MD

boucher
Project Description:

Kimberly studies how the pathogenic bacterium Pseudomonas aeruginosa converts from production of acute to chronic virulence factors. As part of her studies she will compare the gene expression profile of P. aeruginosa during acute infection with bacteria from chronically infected patients with cystic fibrosis. Understanding control of virulence factor production will lead to new therapies.