Development of BTM Nanoparticles for Targeted Chemotherapy of Non-Small Cell Lung Cancer



Lei Peng


Research Mentor:

Dr. Russell Mumper, PhD


Clinical Co-mentor:

Dr. Claire Dees, MD

Home Department Pharmaceutical Sciences
Project Description Nanomedicine has several advantages in cancer therapy, like enhanced permeation and retention (EPR) effect through leaky tumor vasculature, pegylation to escape from host immune system, and active targeting ligand to enhance tumor uptake. BTM nanoparticles are oil-in-water microemulsion previously developed by Dr. Xiaowei Dong in Mumper lab. BTM nanoparticles have been shown to increase solubility of lipophilic drug, and cause ATP depletion to inhibit ATP-dependent drug efflux. My project is designed to develop targeted BTM nanoparticles with paclitaxel or cisplatin for treatment of both sensitive and resistant non-small cell lung cancer. The goal is to decrease toxicity, improve efficacy, and overcome multi-drug resistance in cancer chemotherapy.