Fighting Pseudomonas aeruginosa Bacterial Pneumonia

 

Trainee:

Julianne Huang

huang

Research Mentor:

Matt Redinbo

Redinbo

Clinical Co-mentor:

Stephen Tilley

tilley
Home Department Chemistry
Project Description Critical-care infection rates can be as high as 70% in ICU patients hospitalized for longer than 7 days. Pseudomonas aeruginosa is the principal gram-negative opportunistic bacterial pathogen in nosocomial pneumonias. Furthermore, P. aeruginosa is the leading multi-drug resistant (MDR) gram-negative organism causing ventilator associated pneumonia (VAP) in both ICU and burn patients. We seek to investigate new potential prophylactic agents for this pathogen. The Redinbo group has recently shown that the P. aeruginosa type IV pilus-associated factor PilY1 has several atomic features relevant to initiating and establishing infections. We will use those data to investigate prophylactic therapies for bacterial pneumonia.