Targeted Modulation of Cortical Oscillations through Non-Invasive Transcranial Current Stimulation



Kristin Sellers


Research Mentor:

Flavio Frolich


Clinical Co-mentor:

John Gilmore

Home Department Neurobiology
Project Description Ongoing brain activity synchronizes into physiological and pathological patterns characterized by oscillations. Diseases, such as schizophrenia, are accompanied by characteristic changes in the frequency structure of on-going brain activity. By understanding the role of specific oscillations and changing their activity, novel treatments might be developed for neuropsychiatric disorders. Towards this purpose, my research is composed of three aims: (1) to characterize the mechanisms and functions of physiological cortical oscillations in an animal model using multichannel electrophysiology; (2) to enhance or weaken this ongoing brain activity by applying different waveforms of electric current across the brain in an animal model; and (3) to apply the most effective stimulation waveforms from Aim 2 to humans using a novel technique, transcranial current stimulation, with simultaneous EEG. This work will lead towards the development of non-pharmaceutical, network-level clinical interventions to help treat neuropsychiatric disorders through the targeted application of non-invasive electrical current.