Assessing Mechanisms of Oxidant Stress by Inhaled Pollutants and Effects of Interventions in a Susceptible Population

 

Trainee:

Philip Wages

wages

Research Mentor:

James Samet

samet

Clinical Co-mentor:

Philip Bromberg

bromberg
Home Department Toxicology
Project Description Exposure to many ambient air pollutants, including ozone and particulate matter, have been linked to the progression of cardiovascular disease, ischemic stroke, and asthma associated inflammation. Although these pollutants vary in many aspects, they share oxidant stress as a mechanistic feature of interaction with cells. In some reports it has been shown that intervention strategies, such as the use of dietary antioxidants, reduce the adverse effects associated with exposure to ambient air pollutants. With this understanding, it is the purpose of this project to assess and evaluate the direct and indirect cellular mechanisms that are employed during exposure to common gaseous and particulate pollutants with antioxidant intervention strategies. This project also intends to expand this evaluation of antioxidant use in individuals that are GSTM1 null, which account for 40% of the population, since GSTM1 null individuals tend to have an increased risk to the adverse health effects associated with exposure to ambient air pollutants. Ultimately, this project should complement and broaden already existing clinical data that have indicated susceptible populations by identifying potential oxidative pathways that are involved in exposure to ambient air pollutants.