DPLM Faculty Profiles — Dr. Melissa Miller

Melissa Miller

Melissa B. Miller, PhD, D(ABMM)


Director, Clinical Molecular Microbiology Laboratory

Associate Director, Clinical Microbiology Laboratory

Office: 984-974-1444


Research Interests

My research interests include the use of molecular methodologies to understand the basis of clinical treatment failures and inaccurate laboratory diagnoses with regard to infectious diseases. As the Director of the Clinical Molecular Microbiology Laboratory for UNC Hospitals, I am interested in the use of molecular technology to develop more accurate, cost-effective and timely laboratory tests. Many of these clinical assays are used as research tools to address specific infectious disease questions, such as the prevalence and epidemiology of antimicrobial resistance. In addition, I am interested in the application of molecular techniques in the diagnosis of tuberculosis and respiratory viral diseases and outcome studies aimed at measuring the clinical and financial impact of new diagnostic tests and algorithms.

Selected Publications

Popowitch EB, Miller MB. Performance characteristics of Xpert Flu/RSV XC assay. J Clin Microbiol, 2015, 53:2720-2721.

Muhlebach MS, Heltshe SL, Popowitch EB, Miller MB, Thompson V, Kloster M, Ferkol T, Hoover WC, Schechter MS, Saiman L; the STAR-CF Study Team. Multicenter observational study on factors and outcomes associated with different MRSA types in children with cystic fibrosis. Ann Am Thorac Soc, 2015, 12:864-871.

Lippincott, CK, Miller MB, Van Rie A, Weber DJ, Sena AC, Stout JE. The complexities of Xpert MTB/RIF interpretation. Int J Tuberc Lung Dis, 2015, 19:273-275.

Roshdy DG, Tran A, Lecroy N, Alby K, Zeng D, Ou F-S, Daniels LM, Weber DJ, Miller MB. Impact of microarray-based assay for the identification of positive blood cultures for treatment optimization for patients with streptococcal and enterococcal bacteremia. J Clin Microbiol, 2015, 53:1411-1414.

Nelson JAE, Hawkins JT, Schanz M, Mollan K, Miller MB, Schmitz JL, Fiscus SA. Comparison of the GenProbe Aptima HIV-1 and Abbott HIV-1 qualitative assays with the Roche Amplicor HIV-1 DNA assay for early infant diagnosis using dried blood spots.  J Clin Vir, 2014, 60:418-421.

Dunn JJ and Miller MB. Emerging respiratory viruses other than influenza. Clin Lab Med, 2014, 34:409-430.

Lippincott CK, Miller MB, Popowitch EB, Hanrahan CF, Van Rie A. Xpert MTB/RIF shortens airborne isolation for hospitalized patients with presumptive tuberculosis in the United States.  Clin Infect Dis, 2014, 59:186-192.

Hoots BE, Klein PW, Martin IB, Leone PA, Quinlivan EB, Larson JL, Young JE, Miller MB, Gay CL. Implementation of a collaborative HIV testing model between an emergency department and infectious disease clinic. J Acquir Immune Defic Syndr, 2014, 66:67-70.

Esther CR Jr, Lin FC, Kerr A, Miller MB, Gilligan PH. Respiratory viruses are associated with common respiratory pathogens in cystic fibrosis. Pediatr Pulmonol, 2014, 49:926-931.

Nicolsen NC, Lecroy N, Alby K, Martin KE, Laux J, Lin FC, Daniels L, Weber DJ, Miller MB. Clinical outcomes with rapid detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus from routine blood cultures. J Clin Microbiol, 2013, 51:4126-4129.

Champion EA, Miller MB, Popowitch EB, Hobbs MM, Saiman L, Muhlebach MS; for the STAR-CF Study Team. Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis. Ped Pulmonol, 2014, 49:230-237.

Alby K, Daniels LM, Weber DJ, Miller MB. Development of a treatment algorithm for streptococci and enterococci from positive blood cultures identified with the Verigene BC-GP assay.  J Clin Microbiol, 2013, 51:3869-3871.

Alby K, Gilligan PH, Miller MB. Comparison of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry platforms for the identification of gram-negative rods from patients with cystic fibrosis.  J Clin Microbiol, 2013, 51:3852-3854.

Culton DA, Lachiewicz AM, Miller BA, Miller MB, MacKuen C, Groben P, White B, Cox GM, Stout JE.  Nontuberculous mycobacterial infection after fractionated carbon dioxide laser resurfacing.  Emerg Infect Dis, 2013, 19:365-370.

Popowitch EB, O’Neill SS, Miller MB. Comparison of the BioFire FilmArray RP, Genmark eSensor RVP, Luminex xTAG RVPv1 and Luminex xTAG RVP FAST multiplex assays for the detection of respiratory viruses.  J Clin Microbiol, 2013, 51:1528-1533.

Alby K, Popowitch EB, Miller MB. Comparative evaluation of the Nanosphere Verigene RV+ assay with the Simplexa Flu A/B & RSV Kit for the detection of influenza and respiratory syncytial viruses.  J Clin Microbiol, 2013; 51:352-353.

Heil EL, Daniels LM, Long DM, Rodino KG, Weber DJ, Miller MB. Impact of a rapid peptide nucleic acid fluorescence in situ hybridization assay on treatment of Candida infections.  Am J Health Syst Pharm, 2012, 60:1910-1914.