Liang Xie, PhD
Dr. Xie studies the important roles of Prolyl Hydroxlase Domain Proteins (PHDs) in cardiac function. His particular focuses include the understanding of the molecular mechanisms by which PHDs regulate cardiac contractile function and how their dysregulation contributes to the development of pathophysiologic conditions such as cardiac hypertrophy, cardiac myopathy and arrhythmia.
Pi X, Xie L, Portbury AL, Kumar S, Lockyer P, Li X, Patterson C. NADPH oxidase- generated ROS are required for SDF-1α-stimulated angiogenesis. Arterioscler Thromb Vasc Biol. Accepted.
Xie L (Co-corresponding author), Pi X, Mishra A, Fong G, Peng J, Patterson C. PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest. 2012 Aug 1; 122(8): 2827-36
Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn III EJ, Jin SW, Patterson C. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res. 2012 Aug 17; 111(5): 564-74.
Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Oxygen-regulated beta2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Science Signaling, 2009 July 7; 2 (78) ra33.
Lima B, Lam GK, Xie L, Diesen DL, Villamizar N, Nienaber J, Messina E, Bowles D, Kontos CD, Hare JM, Stamler JS, Rockman HA. Endogenous S-nitrosothiols protect against myocardial injury. Proc Natl Acad Sci USA, 2009; 106(15): 6297-6302.
Pi X, Garin G, Xie L, Zheng QL, Jun-ichi Abe, Yan C, Freeman R, Berk BC. Big mitogen-activated protein kinase (BMK1)/ERK5 regulates endothelial cell angiogenesis via inhibition of hypoxia-inducible factor-1 activity. Circ. Res. 96(11):1145-51 (2005).
Xie L, Johnson RS and Freeman RS. Prolyl-hydroxylase resistant HIF-1α and exposure to low oxygen protect sympathetic neurons from NGF deprivation-induced death by distinct mechanisms. J. Cell Biol. 168(6) (2005).
Jin ZG, Lungu AO, Xie L, Wang M, Wong C, Berk BC. Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24(7): 1186-91(2004).
Freeman RS, Burch RL, Crowder RJ, Lomb DL, Schoell MC, Straub JA and Xie L. NGF deprivation-induced gene expression: After 10 years, where do we stand? Prog. Brain Res. 146:111–126 (2004).
Freeman RS, Hasbani DM, Lipscomb EA, Straub JA and Xie L. SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases. Mol. Cells 16:1–12 (2003).
Blezinger P, Yin G, Xie L, Wang J, Matar M, Bishop JS, Min W. Intravenous delivery of an endostatin gene complexed in cationic lipid inhibits systemic angiogenesis and tumor growth in murine models. Angiogenesis. 3(3):205-10 (1999).