Education and Training:
University of North Carolina at Chapel Hill, 2005
University of North Carolina at Chapel Hill Gene Therapy Center (under R. Jude Samulski), 2008 – 2010
Adeno-associated virus (AAV) vector design and scalable AAV manufacturing for Gene Therapy
My laboratory is focused on developing scalable, animal component-free, cGMP compliant rAAV manufacturing processes. The optimized rAAV manufacturing processes have been and will continue to be developed for manufacturing rAAV for use in Phase I and II human gene therapy clinical trials. These manufacturing processes can produce hundreds to thousands of clinical doses per manufactured lot for numerous genetic ocular disorders. In addition, my secondary focus is designing optimal therapeutic rAAV vector cassettes for gene therapy applications.