Josh Grieger, Ph.D.

Research Assistant Professor

Education and Training:

PhD:

University of North Carolina at Chapel Hill, 2005

Postdoctoral Fellowships:

University of North Carolina at Chapel Hill Gene Therapy Center (under R. Jude Samulski), 2008 – 2010

Special Interests:

Adeno-associated virus (AAV) vector design and scalable AAV manufacturing for Gene Therapy

Research Goals:

My laboratory is focused on developing scalable, animal component-free, cGMP compliant rAAV manufacturing processes.  The optimized rAAV manufacturing processes have been and will continue to be developed for manufacturing rAAV for use in Phase I and II human gene therapy clinical trials.  These manufacturing processes can produce hundreds to thousands of clinical doses per manufactured lot for numerous genetic ocular disorders.  In addition, my secondary focus is designing optimal therapeutic rAAV vector cassettes for gene therapy applications.