Adam D. Pfefferle
Bachelor of Science in Biochemistry and Biology from the University of North Carolina at Chapel Hill
Dissertation Project: The Role of Angiogenesis Factors in Breast Cancer Progression
Breast cancer is a heterogeneous disease consisting of six, clinically important molecular subtypes (Luminal A, Luminal B, Her2-Enriched, Claudin-low, Basal-like, and Normal-like) as they have been shown to be prognostic and predict response to specific therapeutics. I am investigating the molecular differences between these subtypes to better understand their clinical phenotypes. More specifically, these six subtypes have been shown to have different potentials to metastasize in general and to specific sites of relapse. My research project involves investigating angiogenesis factors within and between these subtypes to better understand their metastatic ability and to identify potential drug targets against these biomarkers.
As an undergraduate at UNC, I was mentored by Dr. Susan Lord in the Department of Pathology. My research project involved investigating the correlation between 4-hydroxynonenal protein modifications and atherosclerosis in ApoE-/- mice. After graduating in 2006, I worked in research triangle park for Cogenics, Inc. in their microarray division. In 2008, I became a research technician in Dr. Gregory Wray's lab at Duke University as part of the Institute for Genomic Science & Policy. In his lab, I studied the role of cis-regulatory changes in primate evolution.
During my first year in the BBSP, I rotated with Dr. Ryan Miller in the Department of Pathology and Dr. Jason Lieb in the Department of Genetics before joining the Perou lab. In the Miller lab, my project involved characterizing cell lines derived from mouse models of glioblastomas developed by the Miller lab. In the Lieb lab, I used FAIRE to identify open chromatin marks across different mouse tissues.
I am married to my beautiful wife, Lisa Pfefferle, who I met while she was a graduate student at Duke University. Don't worry, we do not have a 'house divided' as she now cheers for the correct shade of blue. Go Heels!