Bachelor of Science in biology from University of North Carolina at Wilmington
Dissertation Project: Development of Murine Allograft Models of Glioblastoma
My primary research interest is the pathogenesis of glioblastoma (GBM), a devastating malignant primary brain tumor. More specifically I am interested in the development of murine allograft models that faithfully recapitulate the histological and molecular heterogeneity of human GBM. My dissertation project in Dr. Ryan Miller’s laboratory is to determine the role of genetic lesions commonly observed in human GBM on tumorigenesis using murine allograft models. My project also involves defining how the initiating genetic events dictate the efficacy of cancer therapeutics.
During my year in BBSP, I rotated with Dr. Dirk Dittmer in Microbiology and Immunology, Dr. Ryan Miller in Pathology, and Dr. Aravind Asokan in Microbiology and Immunology. With Dr. Dittmer, I was investigating the LANA promoter region of KSHV. With Dr. Miller I was evaluating the effect of temozolomide, a chemotherapeutic commonly used in GBM treatment, on a tumorigenic cell line derived from mouse astrocytes developed in his lab. With Dr. Asokan I was trying to identify the receptors of AAV isolates.