This page provides a brief description of courses offered by the Pathobiology and Translational Science graduate program, and the faculty of the Department of Pathology and Laboratory Medicine. Courses that are infrequently offered are not listed. A complete listing of courses offered by the Department of Pathology and Laboratory medicine can be found in the Graduate School Record, under Pathology.
Courses for Graduate Students and Advanced Undergraduates
PATH 128 Biology of Human Disease (Biology 008; 3 Hours)
This course presents an overview of basic human molecular and cellular biology in the setting of common human diseases. The course emphasizes how an understanding of disease mechanisms provides the knowledge base for informed use of modern health care. BA-level and General College-level natural science. Open to all undergraduates and graduates. No prerequisites. Offered Fall semester. Course Director: H.M. Reisner.
PATH 426 Biology of Blood Diseases (Biology 134; 3 Hours)
An introduction to the biology and pathophysiology of blood and the molecular mechanisms of some human diseases, including malignant neoplasms, anemias, hemophilias, thrombophilias, artheroschlerosis, and viral infections. Prerequisite: Biology 52 or permission of the instructor. Offered Fall semester. Course Director: F.C. Church.
PATH 462 Experimental Pathology (Hours, credits, and instructor to be arranged on an individual basis)
This course involves hands-on research experience in a predetermined instructor's laboratory. Students have the opportunity to learn and apply specific techniques, and to participate in investigations of molecular mechanisms responsible for disease processes (pathobiology). This course may be repeated for credit. Offered Fall and Spring semesters. Course Director: Staff.
PATH 464 Light Microscopy (3 Hours)
This course focuses on practical fundamentals of light microscopy, including optics, contrast mechanisms, fluorescence, laser scanning confocal microscopy, photography, and digital imaging. Prerequisite: Permission of instructor. Offered Spring semester. Course Director: C.R. Bagnell, Jr.
Courses for Graduate Students
PATH 713 Mechanisms of Disease (3 Hours)
A graduate course on cell injury and pathogenesis of disease with emphasis on basic mechanisms at the molecular, cellular, and organismal levels. Prerequisite: None. Three hours lecture and 2.5 hours laboratory each week. Offered Fall semester. Course Directors: J.W. Homeister and A.S. Wolberg.
PATH 714 Mechanisms of Disease Laboratory (2 Hours)
A graduate laboratory course on cell injury and pathogenesis of disease featuring microscopic and gross pathology specimens. Prerequisite: Pathology 713. Can be taken concurrently with Pathology 713. Three hours laboratory each week. Offered Fall semester. Course Director: V.L. Godfrey.
PATH 715 Systemic Pathology (3 Hours)
A graduate course on the pathology and pathophysiology of disease with an emphasis on molecular and cellular mechanisms of disease in organ systems. Prerequisite: Pathology 713. Three hours lecture each week. Offered Spring semester. Course Director: W.B. Coleman.
PATH 716 Systemic Pathology Laboratory (2 Hours)
A graduate laboratory course on pathogenesis of disease of organ systems featuring microscopic and gross pathology specimens. Prerequisite: Pathology 715. Can be taken concurrently with Pathology 715. Three hours laboratory each week. Offered Spring semester. Course Director: W.K. Kaufmann.
PATH 723 Practical Considerations for Translational Research (2 Hours)
Thisis a 2-hour course for biomedical science graduate students that are interested in translation of basic science into clinical practice, irrespective of primary discipline. This course will address (i) core competencies for translational researchers, (ii) fundamental molecular approaches that form the basis for translational science, (iii) fundamentals of personalized medicine, (iv) concepts related to team science, (v) commercialization of basic science, and (vi) industrial translational science. Offered Spring semester. Course Directors: W.B. Coleman and J.W. Homeister.
PATH 725 Cancer Pathology (3 Hours)
This course examines pathobiological features of cancer. An interdiciplinary approach draws from epidemiology, genetics, molecular biology, and clinical medicine to investigate cancer etiology, pathogenesis, prevention, and treatment. Prerequisite: Permission of instructor. Three lecture hours per week, optional 2 hour laboratory per week. Offered Spring semester. Course Director: W.K. Kaufmann.
PATH 726 Human Environmental Disease (2 Hours)
This course will study human disease processes that are induced or exacerbated by our environment. Environmental disease stressors include solar radiation, air and water pollution, bioreactive substances in foods, pesticides, metals, dusts, particles, and allergens. Lectures will emphasize epidemiology, mechanisms of toxicity, and human disease pathogenesis. Offered Fall semester. Course Director: W.K. Kaufmann.
PATH 766 Current Topics in Cardiovascular Biology (3 Hours)
This course emphasizes recent advances in heart and blood vessel development and the molecular mechanisms that regulate cardiovascular cell function. It is taught by UNC faculty of the McAllister Heart Institute and will stress primary literature and current methodologies. In general, course-work will consist of discussion and presentation of assigned manuscripts. Offered Fall semester. Course Director: Christopher Mack.
PATH 767 Molecular and Cellular Biology of Cardiovascular Disease (3 Hours)
This advanced course will explore the underlying pathogenesis of clinical cardiac and vascular disease with the objective of teaching students to understand, investigate, and communicate current concepts of cardiovascular disease. Study topics include hypertensions, lipid metabolism and atherosclerosis, metabolic syndrome, myocardial injury, heart failure, angiogenesis, thrombosis and thrombolysis, genetics and epidemiology of cardiovascular disease, and others. Offered Spring semester. Course Directors: J.W. Homeister and C. Mack.
PATH 792 Seminar in Carcinogenesis (Toxicology 292; 2 Hours)
This course surveys classical and current literature on selected critical issues in carcinogenesis, focusing on the molecular pathogenesis of cancer pathogenesis in . Students discuss experimental methods and observations, as well as theories and generalizations. Offered Spring semester. Course Director: W.B. Coleman.
PATH 801 Cell Cycle Regulation and Cancer (3 Hours)
A graduate-level course designed to teach the "scientific method" and based on student presentations of primary literature and group discussions. The primary goal is to teach students the process by which scientists identify problems, formulate testable hypotheses, collect data through experiments, and eventually establish new models describing biological processes. This course provides a structured mechanism to help facilitate the transition of students from the classroom to the lab and helps develop skills that will be required throughout their scientific careers. Offered Fall semester. Course Director: C. Vaziri.
PATH 900 Research in Pathology (2-12 Hours)
This is a research course in which advanced students in pathology carry on investigations on mechanisms of disease. Six or more laboratory hours per week. May be repeated. Offered Fall and Spring semesters, and Summer sessions. Instructors: Staff.
PATH 994 Doctoral Dissertation (Hours/credits vary)
May be repeated. Offered Fall and Spring semesters, and Summer sessions. Instructors: Staff.