Cardiac biology, protein quality control, the ubiquitin proteasome system, cardiac metabolism, novel therapeutics for cardiac atrophy
The Willis laboratory uses physiologic, molecular, and genetic approaches to study the role of the ubiquitin proteasome system in heart failure and metabolism. The laboratory employs standard molecular techniques, genetically modified animals, and gene discovery tools to expand our understanding of critical quality control mechanisms in heart disease to discover therapeutic targets to exploit.
Solution Structure Of the B-Box Domain Of The Human Tripartite Motif-Containing 63 Protein (MuRF1). Miyamoto K, Kigawa T, Tomizawa T, Koshiba S, Inoue M, Yokoyama S, Riken Structural Genomice PROTEOMICS INITIATIVE (RSGI), 2005/12/8 Homo Sapiens MMDB 39712