PGC Workgroups

Alzheimer's Disease Workgroup (ALZ)

Workgroup Chairs: Danielle Posthuma and Ole Andreassen

Coming soon! (updated 11/11/2016)

Coming Soon! (updated 11/11/2016)

Coming Soon! (updated 11/11/2016)

Anxiety Workgroup (ANX)

ANXgroup

Workgroup Chairs: Jürgen Deckert, Thalia Eley, John Hettema

After an initial meeting of the chairs at the WCPG 2016 in Jerusalem, the PGC Anxiety Workgroup became part of the PGC in 2017, with a kick-off meeting during WCPG 2017 in Orlando. We will have our first data freeze by the end of 2018 the initial analyses will focus on presence/absence of any anxiety disorder.

We plan to conduct genome-wide association studies (GWAS) based on statistically powerful samples of patients with anxiety disorders and healthy individuals with data on anxiety measures. Our long-term objective is to provide further insight into the pathophysiology and neurobiological underpinnings of anxiety disorders through the identification of genetic risk variants, leading to the development of novel treatments or biomarkers.

Our analyses will include GWAS in (i) categorical case-control samples (panic disorder, agoraphobia, general anxiety disorder, social phobia and specific phobia) , (ii) population based samples with dimensional anxiety measures (e.g. ASI, ACQ, GAD-7), with (iii) a special focus on the development of anxiety disorders through life span in child and adolescent cohorts with available follow-up data.

We welcome anyone who is interested to join us. For further information please contact us on pgcanx@kcl.ac.uk.


The Common Genetic Architecture of Anxiety Disorders; https://www.biorxiv.org/content/early/2017/10/16/203844

No ANX funders to report as this time. (updated 5/18/2017)

Attention Deficit Hyperactivity Disorders (ADHD)

PGC ADHD.JPG

Workgroup Chairs: Barbara Franke and Ben Neale

The ADHD workgroup was formed in 1998 with funding from a conference grant from the National Institute of Mental Health. We have been part of the PGC since its inception. During that time, our membership has grown to include 106 investigators from 29 institutions and 14 countries. Our group focuses on the study of ADHD and associated features in children and adults.

Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in psychology, psychiatry, biostatistics, bioinformatics and genetics. Working together we have documented the existence of copy number variants and a polygenic background that mediate the risk for ADHD (please see Select Publications section below). Our current goals are to increase the number of ADHD samples with genomewide association data and to extend our work into genome/exome sequencing.

Past and ongoing work of the ADHD group is at: https://sites.google.com/broadinstitute.org/pcgadhd/home?authuser=0. Please contact or  for additional information on the PGC ADHD workgroup.

If you are a member of the ADHD workgroup and have questions about a specific analysis or if you are interested in joining an ongoing project, please contact the investigator leading that project.

Demontis D., Walters, RK., Martin J., Mattheisen M., Als, TD., Esben Agerbo,... Benjamin M. Neale. (2018). Discovery Of The First Genome-Wide Significant Risk Loci for ADHD. Nature Genetics. http://doi.org/10.1038/s41588-018-0269-7

Albayrak, Ö., Pütter, C., Volckmar, A.-L., Cichon, S., Hoffmann, P., Nöthen, M. M., … Psychiatric GWAS Consortium: ADHD Subgroup. (2013). Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 162B(4), 295–305. http://doi.org/10.1002/ajmg.b.32144

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., … Wray, N. R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45(9), 984–994. http://doi.org/10.1038/ng.2711

Elia, J., Glessner, J. T., Wang, K., Takahashi, N., Shtir, C. J., Hadley, D., … Hakonarson, H. (2012). Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics, 44(1), 78–84. http://doi.org/10.1038/ng.1013

Gao, Q., Liu, L., Chen, Y., Li, H., Yang, L., Wang, Y., & Qian, Q. (2015). Synaptosome-related (SNARE) genes and their interactions contribute to the susceptibility and working memory of attention-deficit/hyperactivity disorder in males. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 57, 132–139. http://doi.org/10.1016/j.pnpbp.2014.11.001

Gao, Q., Liu, L., Li, H.-M., Tang, Y.-L., Wu, Z.-M., Chen, Y., … Qian, Q.-J. (2015). Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 168B(1), 45–53. http://doi.org/10.1002/ajmg.b.32273

Groen-Blokhuis, M. M., Middeldorp, C. M., Kan, K.-J., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., … Boomsma, D. I. (2014). Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. Journal of the American Academy of Child and Adolescent Psychiatry, 53(10), 1123–1129.e6. http://doi.org/10.1016/j.jaac.2014.06.014

Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., … Thapar, A. (2013). High loading of polygenic risk for ADHD in children with comorbid aggression. The American Journal of Psychiatry, 170(8), 909–916. http://doi.org/10.1176/appi.ajp.2013.12081129

Hart, A. B., Gamazon, E. R., Engelhardt, B. E., Sklar, P., Kähler, A. K., Hultman, C. M., … Palmer, A. A. (2014). Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proceedings of the National Academy of Sciences of the United States of America, 111(16), 5968–5973. http://doi.org/10.1073/pnas.1318810111

Hinney, A., Scherag, A., Jarick, I., Albayrak, Ö., Pütter, C., Pechlivanis, S., … Psychiatric GWAS Consortium: ADHD subgroup. (2011). Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 156B(8), 888–897. http://doi.org/10.1002/ajmg.b.31246

Jarick, I., Volckmar, A.-L., Pütter, C., Pechlivanis, S., Nguyen, T. T., Dauvermann, M. R., … Hinney, A. (2014). Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder. Molecular Psychiatry, 19(1), 115–121. http://doi.org/10.1038/mp.2012.161

Kim, S. M., Kim, Y. A., Kim, S. Y., Kim, S. H., Cho, K. W., & Kim, S. Z. (2011). Presence of dendroaspis natriuretic peptide and its binding to NPR-A receptor in rabbit kidney. Regulatory Peptides, 167(1), 42–49. http://doi.org/10.1016/j.regpep.2010.11.010

Klein, M., van der Voet, M., Harich, B., van Hulzen, K. J. E., Onnink, A. M. H., Hoogman, M., … Psychiatric Genomics Consortium ADHD Working Group. (2015). Converging evidence does not support GIT1 as an ADHD risk gene. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics. http://doi.org/10.1002/ajmg.b.32327

Martin, J., Cooper, M., Hamshere, M. L., Pocklington, A., Scherer, S. W., Kent, L., … Holmans, P. (2014). Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry, 53(7), 761–770.e26. http://doi.org/10.1016/j.jaac.2014.03.004

Martin, J., O’Donovan, M. C., Thapar, A., Langley, K., & Williams, N. (2015). The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry, 5, e506. http://doi.org/10.1038/tp.2015.5

Mick, E., Todorov, A., Smalley, S., Hu, X., Loo, S., Todd, R. D., Faraone, S. V. (2010). Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 898–905.e3. http://doi.org/10.1016/j.jaac.2010.02.014

Neale, B. M., Medland, S. E., Ripke, S., Asherson, P., Franke, B., Lesch, K.-P., … Psychiatric GWAS Consortium: ADHD Subgroup. (2010). Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 884–897. http://doi.org/10.1016/j.jaac.2010.06.008

Neale, B. M., Medland, S., Ripke, S., Anney, R. J. L., Asherson, P., Buitelaar, J., … IMAGE II Consortium Group. (2010). Case-control genome-wide association study of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 906–920. http://doi.org/10.1016/j.jaac.2010.06.007

Ramos-Quiroga, J.-A., Sánchez-Mora, C., Casas, M., Garcia-Martínez, I., Bosch, R., Nogueira, M., … Ribasés, M. (2014). Genome-wide copy number variation analysis in adult attention-deficit and hyperactivity disorder. Journal of Psychiatric Research, 49, 60–67. http://doi.org/10.1016/j.jpsychires.2013.10.022

Richards, J. S., Hartman, C. A., Franke, B., Hoekstra, P. J., Heslenfeld, D. J., Oosterlaan, J., … Buitelaar, J. K. (2015). Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour. European Child & Adolescent Psychiatry, 24(2), 209–217. http://doi.org/10.1007/s00787-014-0567-2

Salatino-Oliveira, A., Wagner, F., Akutagava-Martins, G. C., Bruxel, E. M., Genro, J. P., Zeni, C., … Hutz, M. H. (2015). MAP1B and NOS1 genes are associated with working memory in youths with attention-deficit/hyperactivity disorder. European Archives of Psychiatry and Clinical Neuroscience. http://doi.org/10.1007/s00406-015-0626-9

Stergiakouli, E., Hamshere, M., Holmans, P., Langley, K., Zaharieva, I., deCODE Genetics, … Thapar. (2012). Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. The American Journal of Psychiatry, 169(2), 186–194.

Yang, L., Neale, B. M., Liu, L., Lee, S. H., Wray, N. R., Ji, N., … Hu, X. (2013). Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 162B(5), 419–430. http://doi.org/10.1002/ajmg.b.32169

No ADHD funders to report as this time. (updated 5/1/2016)

Autism Spectrum Disorder (ASD)

Workgroup Chairs: Mark Daly and Anders Børglum

Coming Soon! (updated 5/1/2016)

Coming Soon! (updated 5/1/2016)

Coming Soon! (updated 5/1/2016)

Bipolar Disorders (BIP)

Workgroup Chair: Ole Andreassen