UNC- Chapel Hill
Denis Tsygankov

Denis Tsygankov

Research Assistant Professor
dtsygank@med.unc.edu






Research

I am applying physical and mathematical approaches to elucidate the mechanisms of biological processes on both the molecular and systems levels. By integrating modeling and simulations with novel biological imaging techniques, I study the interplay between cell signaling and mechanics at different scales. Most recently I have been focusing on the role of CCM proteins in endothelial cell tube formation, analyzing the regulation of cellular morphodynamics, and developing computer vision algorithms to study cell motility. My past research experiences also include investigations of energy transduction in molecular motors and the role of the tumor suppressor p16INK4A in aging.



Publications


Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM. Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12420-5. doi: 10.1073/pnas.1404487111. Epub 2014 Aug 12.
(Pubmed | Journal)

Tsygankov D, Chu PH, Chen H, Elston TC, Hahn KM. User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters. Methods Cell Biol. 2014;123:409-27. doi: 10.1016/B978-0-12-420138-5.00022-7.
(Pubmed | Journal)

Tsygankov D, Bilancia CG, Vitriol EA, Hahn KM, Peifer M, Elston TC. CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol. 2014 Feb 3;204(3):443-60
(Pubmed | Journal)

Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M. Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo. Dev Cell. 2014 Feb 24;28(4):394-408
(Pubmed | Journal)

Karginov AV, Tsygankov D, Berginski M, Chu P-H, Trudeau ED, Yi JJ, Gomez G, Elston TC, Hahn KM. Dissecting motility signaling through activation of specific Src-effector complexes. Nature Chem Biol. 2014 Apr;10(4):286-90. doi: 10.1038/nchembio.1477. Epub 2014 Mar 9.
(Pubmed | Journal)

Allen RJ, Tsygankov D, Zawistowski JS, Elston TC, Hahn KM. Automated line scan analysis to quantify biosensor activity at the cell edge. Methods. 2014 Mar 15;66(2):162-7. doi: 10.1016/j.ymeth.2013.08.025. Epub 2013 Aug 30.
(Pubmed | Journal)

Tsygankov D, Serohijos AW, Dokholyan NV, Elston TC. A physical model reveals the mechanochemistry responsible for dynein's processive motion. Biophys J. 2011 Jul 6;101(1):144-50. doi: 10.1016/j.bpj.2011.05.043.
(Pubmed | Journal)

Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC. A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39): 16562-16567.
(Pubmed | Journal)

Serohijos AWR, Tsygankov D, Liu S, Elston TC, Dokholyan NV. Multiscale approaches for studying energy transduction in dynein. Phys Chem Chem Phys. 2009 Jun 28; 11(24): 4840-50.
(Pubmed | Journal)

Tsygankov D, Serohijos AW, Dokholyan NV, Elston TC. Kinetic models for the coordinated stepping of cytoplasmic dynein. J Chem Phys. 2009 Jan 14;130(2):025101
(Pubmed | Journal)

Tsygankov D, Fisher ME. Kinetic models for mechanoenzymes: Structural aspects under large loads. J Chem Phys. 2008 Jan 7; 128(1): 015102
(Pubmed | Journal)

Tsygankov D, Fisher ME. Mechanoenzymes under superstall and large assisting loads reveal structural features. Proc Natl Acad Sci USA. 2007 Dec 4;104 (49): 19321–19326
(Pubmed | Journal)

Tsygankov D, Lindén M, Fisher ME. Back-stepping, hidden substeps, and conditional dwell times in molecular motors Phys Rev E. 2007 Feb; 75(2 Pt 1): 021909
(Pubmed | Journal)

Tsygankov D, Wiesenfeld K. Weak-link synchronization. Phys Rev E. 2006 Feb; 73(2 Pt 2): 026222
(Pubmed | Journal)

Tsygankov D, Wiesenfeld K. Spontaneous formation of inert oscillator pairs. Phys Lett A. 2004 Mar; 325: 51–56
(Journal)

Tsygankov D, Wiesenfeld K. Spontaneous synchronization in a Josephson transmission line. Phys Rev E. 2002 Sep; 66(3 Pt 2A): 036215
(Pubmed | Journal)

Karelsky KV, Papkov VV, Petrosyan AS, Tsygankov. Particular solutions of shallow-water equations over a non-flat surface. Phys Lett A. 2000 May; 271: 341–348
(Journal)


Educational Background

Ph.D. in Physics,
     Georgia Institute of Technology, Atlanta, GA, USA, August 2005;
M.S. in Applied Physics and Mathematics,
     Moscow Institute of Physics and Technology, Russia, June 2000;
B.S. in Applied Physics and Mathematics,
     Moscow Institute of Physics and Technology, Russia, June 1998.