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The Itch Receptor - Kate Lansu leads research on opioid-induced itching

The Itch Receptor - Kate Lansu leads research on opioid-induced itching

Researchers in the department of Pharmacology link orphan receptor MRGRPX2 to opioid-induced itching and create a tool to study the receptor more precisely.

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H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp, MD, Director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Joint Professor of Pharmacology has been honored with the Hyman L. Battle Distinguished Cancer Research Award along with Jenny P.Y. Ting, PhD, UNC Lineberger member and William Rand Kenan Professor of Genetics,

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Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

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 Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Alison Xiaoqiao Xie, research assistant professor in Ken McCarthy's lab, is first author on paper published in JCI Insight this week. Ken D. McCarthy, professor of pharmacology, is senior author and Jakovin J. Lee, is a co-author.

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This is LSD attached to a brain cell serotonin receptor

This is LSD attached to a brain cell serotonin receptor

For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.

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Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.

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Inside the world of cell signaling: a G-protein breakthrough

Inside the world of cell signaling: a G-protein breakthrough

UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

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Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."

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