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Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.

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Inside the world of cell signaling: a G-protein breakthrough

Inside the world of cell signaling: a G-protein breakthrough

UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

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Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

Engineering Control of Cellular Proteins - An Ontogenetics Breakthrough

UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."

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Megan Agajanian Wins 1st Place Poster Prize!

Megan Agajanian Wins 1st Place Poster Prize!

Pharmacology graduate student, Megan Agajanian wins first place in UNC LIneberger Annual Scientific Retreat poster competition.

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Henrik Dolman Named Chair of the Department of Pharmacology

Henrik Dolman Named Chair of the Department of Pharmacology

Henrik Dohlman, PhD, has been named Chair of the Department of Pharmacology, effective Oct. 1.

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Scientists discover interplay of yin-yang antagonists vital for cell division

Scientists discover interplay of yin-yang antagonists vital for cell division

Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.

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Researchers build a better opioid painkiller from scratch

Researchers build a better opioid painkiller from scratch

The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.

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