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Cells contain an essentially continuous network of organized molecules, with large structures such as cytoskeletal “girders” and membrane domains forming a shifting scaffold for the organization of many smaller molecular assemblies. These structures are highly dynamic; both their position and composition are controlled to regulate cell behavior and integrate information traveling through different signaling pathways. To understand these dynamic aspects of cell signaling we are developing new tools to visualize and control protein behavior within living cells. We are focusing on interconnected signaling networks that control many different cell behaviors, hoping ultimately to shed light on their role in specific diseases; GTPase, MAP kinase and adhesion signaling networks depend on the transient formation of localized complexes and scaffold interactions to regulate neuronal development, cell movement, and engulfment behaviors such as phagocytosis and macropinocytosis. Some current research directions:
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Questions or Comments? Contact Hahn Lab. |
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