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UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

The lab of Jean Cook, PhD, joint professor in the department of pharmacology, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous.

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Scientists Take a Big Step toward Building a Better Opioid ...

Scientists Take a Big Step toward Building a Better Opioid ...

In a paper published in Cell, research led by Bryan Roth, MD, PhD, and Roth lab members, Tao Ch, PhD and Daniel Wacker, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.

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UNC School of Medicine to Launch Computational Medicine Program

UNC School of Medicine to Launch Computational Medicine Program

Led by Timothy Elston, PhD, and Chuck Perou, PhD, the university-wide program aims to advance personalized medicine for patients.

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A microscope maker

A microscope maker

Wesley Legant, PhD, Assistant Professor in Pharmacology, is highlighted in a Nature article on a do-it-yourself approach to microscopy that lead to the development of light sheet microscopy.

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NIH renews grant funding the Bowles Alcohol Research Center

NIH renews grant funding the Bowles Alcohol Research Center

The center, established 20 years ago and led by Fulton Crews, PhD, Distinguished Professor in Pharmacology, will receive more than $8.7 million over five years to continue research on the effects of alcohol on the brain. Other pharmacology faculty who are PIs on the the grant are Clyde Hodge, PhD, Zoe McElligott, PhD, Tom Kash, PhD, Melissa Herman, PhD and Leslie Morrow, PhD.

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Could this Protein Protect People against Coronary Artery Disease?

Could this Protein Protect People against Coronary Artery Disease?

Research led by UNC’s Jonathan Schisler, PhD, Assistant Professor of Pharmacology, showed much lower levels of the protein CXCL5 in older people with clogged arteries.

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How do adult brain circuits regulate new neuron production?

How do adult brain circuits regulate new neuron production?

In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus.

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Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen, MD, assistant professor of medicine and pharmacology, delivered the 2017 Whitehead Lecture. The event, which serves as an unofficial convocation of the UNC School of Medicine, has been held annually since 1947.

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CSF Students Give Research Presentations

CSF Students Give Research Presentations

Our 2017 Carolina Summer Fellowship students gave their research presentations today as they end the program. Congratulations to all!

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Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

UNC receives $1.5-million grant to study the role of a clotting protease and receptor in the innate immune response to viral infections. Nigel Mackman, PhD, Distinguished Professor of Medicine, and joint Professor of Pharmacology, is the principal investigator of a 4-year $1.5-million award from the National Heart Lung and Blood Institute. This grant will determine the role of thrombin activation of protease-activated receptor 1 in the innate immune response to viral infections.

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections - Read More…

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

The Willis laboratory has been recognized by the Society of Endocrinology for excellence in endocrine research and practice and for contributions to the wider biomedical and biological sciences field. The award was chosen by a panel on the basis of originality, scientific content, presentation and contribution to the field. The award will be presented to Monte Willis, PhD, at the Society’s Annual BES Conference in Harrogate, UK on November 7.

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Jordan Walter Successfully Defends His PhD!

Jordan Walter Successfully Defends His PhD!

Congratulations to Jordan Walter, graduate student in the Crews Lab, for successfully defending His PhD Thesis!

Jordan Walter Successfully Defends His PhD! - Read More…

In ovarian cancer, researchers uncover new drivers of cell division

In ovarian cancer, researchers uncover new drivers of cell division

UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.

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Devon Blake Awarded  NRSA F31 Predoctoral Fellowship

Devon Blake Awarded NRSA F31 Predoctoral Fellowship

Disrupted signaling pathways that lead to aberrant cell movement are a hallmark of invasive and metastatic cancers. The small GTPase RhoA has a well-established role in normal cell biology, but the consequences of cancer-associated RhoA mutations are unknown. Devon will extensively characterize the effect of these mutations on the properties of RhoA in order to better understand how mutations in RhoA contribute to cancer

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