UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."
Pharmacology graduate student, Megan Agajanian wins first place in UNC LIneberger Annual Scientific Retreat poster competition.
Henrik Dohlman, PhD, has been named Chair of the Department of Pharmacology, effective Oct. 1.
Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.
The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.