Faculty News

How did Gonorrhea Become a Drug-resistant Superbug?

How did Gonorrhea Become a Drug-resistant Superbug?

Scientists led by Rob Nicholas, PhD, at the UNC School of Medicine show how the gonorrhea bacterium resists last-resort antibiotic ceftriaxone while maintaining a robust growth rate.

How did Gonorrhea Become a Drug-resistant Superbug? - Read More…

Jen Jen Yeh named Smithies Investigator

Jen Jen Yeh named Smithies Investigator

The UNC School of Medicine has selected Jen Jen Yeh, MD, professor and vice chair of research for the department of surgery, and joint professor of pharmacology, for one of two annual awards in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

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Scientific Breakthrough Could Lead to Better Antipsychotic Drugs

Scientific Breakthrough Could Lead to Better Antipsychotic Drugs

Published in Nature, research from the lab of Bryan L. Roth, MD, PhD, Distinguished Professor of Pharmacology, revealed the first-ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug – a much-needed discovery in the quest to create effective drugs with fewer side effects to treat bipolar disorder, schizophrenia, and other conditions.

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UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

UNC Scientists Discover Proteins Keeping Stem Cells in their Undifferentiated State

The lab of Jean Cook, PhD, joint professor in the department of pharmacology, found how a chain of proteins called an MCM complex could enable the fast cell-division that makes some forms of cancer so dangerous.

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Scientists Take a Big Step toward Building a Better Opioid

Scientists Take a Big Step toward Building a Better Opioid

In a paper published in Cell, research led by Bryan Roth, MD, PhD, and Roth lab members, Tao Ch, PhD and Daniel Wacker, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.

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UNC School of Medicine to Launch Computational Medicine Program

UNC School of Medicine to Launch Computational Medicine Program

Led by Timothy Elston, PhD, and Chuck Perou, PhD, the university-wide program aims to advance personalized medicine for patients.

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A microscope maker

A microscope maker

Wesley Legant, PhD, Assistant Professor in Pharmacology, is highlighted in a Nature article on a do-it-yourself approach to microscopy that lead to the development of light sheet microscopy.

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NIH renews grant funding the Bowles Alcohol Research Center

NIH renews grant funding the Bowles Alcohol Research Center

The center, established 20 years ago and led by Fulton Crews, PhD, Distinguished Professor in Pharmacology, will receive more than $8.7 million over five years to continue research on the effects of alcohol on the brain. Other pharmacology faculty who are PIs on the the grant are Clyde Hodge, PhD, Zoe McElligott, PhD, Tom Kash, PhD, Melissa Herman, PhD and Leslie Morrow, PhD.

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How do adult brain circuits regulate new neuron production?

How do adult brain circuits regulate new neuron production?

In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus.

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Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture

Brian Jensen, MD, assistant professor of medicine and pharmacology, delivered the 2017 Whitehead Lecture. The event, which serves as an unofficial convocation of the UNC School of Medicine, has been held annually since 1947.

Brian Jensen Receives The Hyman Battle Distinguished Excellence in Teaching Award and Delivers Whitehead Lecture - Read More…

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections

UNC receives $1.5-million grant to study the role of a clotting protease and receptor in the innate immune response to viral infections. Nigel Mackman, PhD, Distinguished Professor of Medicine, and joint Professor of Pharmacology, is the principal investigator of a 4-year $1.5-million award from the National Heart Lung and Blood Institute. This grant will determine the role of thrombin activation of protease-activated receptor 1 in the innate immune response to viral infections.

Mackman to lead 4-year $1.5-million award study into role of clotting protease and receptor in the innate immune response to viral infections - Read More…

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

Willis laboratory recognized by Society of Endocrinology for excellence in endocrine research

The Willis laboratory has been recognized by the Society of Endocrinology for excellence in endocrine research and practice and for contributions to the wider biomedical and biological sciences field. The award was chosen by a panel on the basis of originality, scientific content, presentation and contribution to the field. The award will be presented to Monte Willis, PhD, at the Society’s Annual BES Conference in Harrogate, UK on November 7.

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In ovarian cancer, researchers uncover new drivers of cell division

In ovarian cancer, researchers uncover new drivers of cell division

UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.

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Leslie Parise elected UNC-Chapel Hill Faculty Chair

Leslie Parise elected UNC-Chapel Hill Faculty Chair

Parise is completing a second term on the Faculty Executive Committee (FEC) and Faculty Council, where she pushed for improvements to the campus work-life environment and initiated discussions that led to creation of the Chancellor’s Science Scholars Program in the College of Arts and Sciences.

Leslie Parise elected UNC-Chapel Hill Faculty Chair - Read More…

H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp recognized for career achievements in cancer research

H. Shelton Earp, MD, Director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Joint Professor of Pharmacology has been honored with the Hyman L. Battle Distinguished Cancer Research Award along with Jenny P.Y. Ting, PhD, UNC Lineberger member and William Rand Kenan Professor of Genetics,

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Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

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 Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo

Alison Xiaoqiao Xie, research assistant professor in Ken McCarthy's lab, is first author on paper published in JCI Insight this week. Ken D. McCarthy, professor of pharmacology, is senior author and Jakovin J. Lee, is a co-author.

Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo - Read More…

This is LSD attached to a brain cell serotonin receptor

This is LSD attached to a brain cell serotonin receptor

For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.

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