The Elston lab's paper "Positive roles for negative regulators in the mating response of yeast," Molecular Systems Biology, June 5, 2012, has been recommended as being of special significance in the field of Genomics & Genetics by Anuj Kumar and Cole Johnson from the F1000 Faculty.
Our congratulations to Dr. Tim Elston, John Houser, the first author on the paper, and the other co-authors: Eintou Ford, Michael Nagiec, and Beverly Errede, all from UNC.
Anuj Kumar and Cole Johnson of the F1000 explain the paper's importance thusly:
"In this interesting paper, the authors investigate Ste12p-mediated transcriptional regulation of the yeast pheromone signaling network (mating response). Specifically, the authors utilized integrated computational and experimental approaches to generate an ordinary differential equation (ODE)-based mathematical model that not only accurately mimics the observed in vivo pheromone response of yeast but can also predict the response of this network to genetic perturbations, offering a predictive understanding of the yeast mating response."
|John Houser, Elston
lab member and first
author on the paper
"Living organisms display a remarkable ability to quickly and appropriately respond to changes in their extracellular environment. Their response is often mediated through tightly coordinated gene expression using multiple control mechanisms integrated into a complex gene regulatory network. Despite continual research into the design principles of complex signaling networks, our ability to reconstruct the multifaceted gene regulatory networks observed in nature is in its infancy. Here, the authors further our predictive understanding of genetic regulatory networks by combining computational and experimental methodologies to study transcriptional regulation mediated by Ste12 in budding yeast. Specifically, Houser et al. developed a mathematical model that can accurately describe multiple, unique characteristics of the Ste12-mediated pheromone response."
To read the full article explaining the paper's importance go to: http://f1000.com/717948916
About the F1000: "Faculty of 1000 (F1000) identifies and evaluates the most important articles in biology and medical research publications. Articles are selected by a peer-nominated global 'Faculty' of the world's leading scientists and clinicians who then rate them and explain their importance." (from the F1000 Research website: http://f1000.com/about/whatis)
You can find out more about the F1000 at http://f1000.com/tour