UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."
The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.
Thomas L. Kash, PhD has been appointed as the John Andrews Distinguished Professor of Alcohol Studies.
The Song lab will use the fund to study the cellular targets of Zika Virus (ZIKV) in the adult brain using a mouse model of ZIKV pathogenesis.
The image is from their paper, "Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory, " published in collaboration with Stephanie Gupton's lab in the same edition.
UNC School of Medicine researchers have found a protein that appears to protect against coronary artery disease in older people with surprisingly clear arteries.
Study could lead to new drug development targets for forms of anxiety that are more pathological, such as those associated with excessive alcohol intake or opiate abuse.
The Hahn, Kuhlman and Kasai labs developed a genetically encoded probe that can label and optically erase synapses that were enlarged or generated by motor learning. Dense labeling of synapses was found in a small subset of pyramidal neurons, and irradiation with blue light erased motor memory.
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Scientists from the UNC / NC State joint biomedical engineering department are creating a new kind of research tool that will be nearly indistinguishable from the human gastrointestinal tract.
UNC Lineberger Comprehensive Cancer Center researchers and eight other leading cancer research institutions have won a five-year, $12 million grant to try to find treatments for a group of cancers linked to mutations in the NF1 gene.
Using a new ‘chemogenetic’ technique invented at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.
Dr. Mike Miley is co-PI, along with Dr. TinChung Leung of UNC State, on one of six three-year grants funded by the University of North Carolina General Administration to support game-changing faculty research in areas of strategic importance to the state.
Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.
Bryan Roth and collaborator Raymond Stevens' Nature paper on "Molecular control of δ-opioid receptor signalling" was selected as one of the Best Breakthroughs in Signaling in 2014 in the Jan. 6 issue of Science Signaling. Gustavo Fenalti was first author on the paper.