With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.
Alison Xiaoqiao Xie, research assistant professor in Ken McCarthy's lab, is first author on paper published in JCI Insight this week. Ken D. McCarthy, professor of pharmacology, is senior author and Jakovin J. Lee, is a co-author.
For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.
UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.
UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC scientists expand the use of light to control protein activity in cells. Klaus Hahn and Nikolay Dokholyan have published a paper in Science, detailing how they use light- or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. The title of the paper is "Engineering extrinsic disorder to control protein activity in living cells."
Although mutated versions of the protein Cdh1 have not been found in cancers, the protein’s degradation at a key moment during the cell cycle may spur on cancerous cell division.
The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.
Thomas L. Kash, PhD has been appointed as the John Andrews Distinguished Professor of Alcohol Studies.
The Song lab will use the fund to study the cellular targets of Zika Virus (ZIKV) in the adult brain using a mouse model of ZIKV pathogenesis.
The image is from their paper, "Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory, " published in collaboration with Stephanie Gupton's lab in the same edition.
UNC School of Medicine researchers have found a protein that appears to protect against coronary artery disease in older people with surprisingly clear arteries.
Study could lead to new drug development targets for forms of anxiety that are more pathological, such as those associated with excessive alcohol intake or opiate abuse.
The Hahn, Kuhlman and Kasai labs developed a genetically encoded probe that can label and optically erase synapses that were enlarged or generated by motor learning. Dense labeling of synapses was found in a small subset of pyramidal neurons, and irradiation with blue light erased motor memory.
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.