The Hahn, Kuhlman and Kasai labs developed a genetically encoded probe that can label and optically erase synapses that were enlarged or generated by motor learning. Dense labeling of synapses was found in a small subset of pyramidal neurons, and irradiation with blue light erased motor memory.
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Scientists from the UNC / NC State joint biomedical engineering department are creating a new kind of research tool that will be nearly indistinguishable from the human gastrointestinal tract.
UNC Lineberger Comprehensive Cancer Center researchers and eight other leading cancer research institutions have won a five-year, $12 million grant to try to find treatments for a group of cancers linked to mutations in the NF1 gene.
Using a new ‘chemogenetic’ technique invented at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.
Dr. Mike Miley is co-PI, along with Dr. TinChung Leung of UNC State, on one of six three-year grants funded by the University of North Carolina General Administration to support game-changing faculty research in areas of strategic importance to the state.
Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.
Bryan Roth and collaborator Raymond Stevens' Nature paper on "Molecular control of δ-opioid receptor signalling" was selected as one of the Best Breakthroughs in Signaling in 2014 in the Jan. 6 issue of Science Signaling. Gustavo Fenalti was first author on the paper.
Congratulations to Dr. Mauro Calabrese, Assistant Professor of Pharmacology, who has received the 2014 Basil O’Connor Scholar Research Award from the March of Dimes Foundation.
Two Pharmacology professors along with four other UNC professors elected Fellows of the AAAS.
The National Institute of Mental Health director Tom Insel recognized Byran L. Roth, MD, PhD, for his innovative research tool.
Joseph DeSimone, PhD, the Chancellor’s Eminent Professor of Chemistry and a joint Professor in the Department of Pharmacology, has been elected to the Institute of Medicine, one of the highest honors in the fields of health and medicine. This election represents the third time Desimone has been elected to a U.S. National Academy.
Roth’s research to create innovative tools for neuroscientists and discover potential targets for therapeutics has earned him one of the highest honors in the field of medicine.
Led by Bryan L. Roth, MD, PhD, three UNC labs will develop the next generation neuroscience tool-kit to accelerate novel treatments for neuropsychiatric and a host of other diseases. ~by Mark Derewicz
Bryan Roth and Gary Johnson Awarded NIH Grants From the NIH Illuminating the Druggable Genome Initiative
Drs. Bryan Roth and Gary Johnson receive 2 of 9 grants awarded by the NIH Illuminating the Druggable Genome Initiative which is supporting research to study 4 of the most commonly drug-targeted protein families
Zefeng Wang's paper published in Cancer Cell this week shows that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing.